Isotopic Labeling Strategies

The new development of isotopic labeling strategies for quantitative glycomics will help to revolutionize the field of high-throughput screening of comparative glycomics. CD BioGlyco has professional technicians and advanced instruments to develop a variety of strategies for the isotopic labeling of glycans. We look forward to providing our customers with professional scientific services in research associated with glycomics quantitation.

Background

With the development of glycobiology, the correlations between glycosylation and various biological processes and diseases are gradually being recognized, which increases the demand for strategies of glycomic quantitation. Sensitive monitoring of the abundance and structural changes of glycans is the key to glycomics. Currently, this is achieved through multiple strategies using several analytical techniques such as liquid chromatography, capillary electrophoresis, and mass spectrometry. In order to achieve higher sensitivity, glycans are usually labeled with ionic and/or hydrophobic reagents to enhance the detection in spectroscopy and mass spectrometry.

Recently, isotopic labeling strategies have also been presented as a very feasible measurement enabling relative quantitation. Methods for isotopically labeled glycans are useful for discriminating differentiated cells and their glycomic features, monitoring disease and/or therapeutic progression, diagnosing disease states, and determining drug activity. Now we have developed several quantitative strategies for glycomics that can reliably and sensitively monitor glycan changes associated with different biological conditions and diseases, including metabolic labeling, chemical labeling, and enzymatic catalyzed labeling.

Strategies

Advantages of Us

  • Synthetically facile, cost-effective labeling technologies
  • Excellent identification ability
  • High-resolution mass spectrometry platform to provide high-quality data
  • Strict quality control to ensure optimal qualitative and quantitative results.

CD BioGlyco has developed many strategies for glycans isotope labeling to monitor glycan changes by taking advantage of the diverse properties of glycans recently. We aim to provide our clients with high-quality and efficient scientific services to accelerate their research. If you have scientific needs in the field of glycomic quantitation, please contact us for more detailed information.

Reference:

  1. Cummings, R.D.; Smith, D.F. Isotopic labeling of glycans for quantitative glycomics. Handbook of Glycomics. 2010, 81:83–93.
This service is for Research Use Only, not intended for any clinical use.

Christmas

About Us

CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.

Contact Us

Copyright © CD BioGlyco. All rights reserved.