Cancer antigen 125 (CA125) is the most used serum marker and the most trusted method for early detection of ovarian cancer. CD BioGlyco offers multiple highly sensitive and specific ovarian cancer assays based on CA125. We look forward to being your scientific assistant in the field of glycoproteomics.
Endometrial cancer, cervical cancer and ovarian cancer are three of the most common malignancies of the female reproductive tract. Of these three cancers, ovarian cancer, although rare, is the most lethal, primarily because approximately three-quarters of ovarian cancer cases are diagnosed at an advanced stage and the disease has spread to organs outside the ovaries. The poor prognosis for this cancer is directly attributable to the lack of sensitive and reliable screening assays and our limited understanding of its chemoresistance and recurrence mechanisms. Therefore, the establishment of appropriate early screening tests for ovarian cancer has long been sought.
One of the most commonly used protein tests for the initial detection of various types of cancer, including ovarian cancer, is based on serum levels of CA125 cancer antigen, which is a very important tumor glyco-biomarker with a normal level at 35 U/mL. This level is elevated in advanced ovarian cancer and in malignant tumors such as colon, breast, pericardium, pancreas and other epithelial cell diseases. Today, screening for ovarian cancer using CA125 is performed in combination with physical examination and its early detection is critical to achieving an effective ovarian cancer diagnosis so that treatment programs can be initiated at the onset of the disease.
CD BioGlyco has developed sensitive, reliable and rapid methods for detecting low levels of CA125 that are indicative of early ovarian cancer. The strategies we provide include but are not limited to:
Our glyco-biomarker CA125 detection service is powered by a suite of cutting-edge technologies, ensuring unparalleled accuracy and sensitivity. A cornerstone of our approach is the use of particular lectin-based assays and advanced immunoassay techniques. We employ robust mass spectrometry platforms, including liquid chromatography-tandem mass spectrometry (LC-MS/MS), for the precise identification and quantification of glycosylation patterns associated with CA125. Furthermore, our service integrates high-throughput microfluidic systems, enabling efficient processing of numerous samples while maintaining exceptional data quality. These integrated technologies enable the detailed glycoprofiling of CA125, providing a deeper understanding beyond simple concentration measurements.
Technology: Lyotropic chromonic liquid crystals (LCLCs), Transmission spectrometry, Spectrometric quantitation
Journal: Biosensors
Published: 2021
IF: 4.9
Results: In this study, researchers constructed a label-free biosensor that uses transmission spectroscopy to quantitatively analyze the cancer biomarker CA125 in the visible light range. Research shows that when the planar arrangement of LCLC is captured at the LC-glass interface by biological molecules such as CA125 antibody-antigen complexes, optical signals related to the concentration of biological molecules and wavelength are generated. Through quantitative analysis using the light attenuation ratio parameter, researchers found that its detection sensitivity is comparable to or even superior to that of thermally induced liquid crystals, providing a new perspective on the application of LCLC in the field of biosensing.
Fig.1 LCLC-based protein detection and immunoassay. (Shaban, et al., 2021)
CD BioGlyco is committed to developing new cancer glyco-biomarker assays including CA125 assay to reduce the cost of detection systems and simplify cancer screening procedures. If you have a need for glyco-biomarker detection services, please contact us for further information.
To further support your research and development endeavors related to glyco-biomarkers and beyond, CD BioGlyco offers a range of complementary services:
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