Saccharides, compounds formed by covalent bonding of saccharides, biomolecules (such as proteins, peptides, lipids, nucleic acids, and antibodies), and other small molecules are ubiquitous. They are located on the cell surface and inside the cell and play a key role in processes such as cell interaction development of vaccines against cancer, viral and bacterial infections, and many other diseases. The conjugation of sugar and other substances also improves the original properties of these substances, such as stability and solubility.
Proteins and nucleic acids can be obtained in a homogeneous form through recombinant expression and polymerase chain reaction, respectively. Unlike them, the biosynthesis of sugars and glycoconjugates does not have a fixed template and uniform model. Therefore, sugar-related substances isolated from biological samples usually exist in the form of heterogeneous mixtures of different glycan structures. To solve this problem, CD BioGlyco has developed different strategies for obtaining homogenous sugar-related substances, including chemical, enzymatic, and chemoenzymatic methods, and can also provide different modifications according to customer needs. Our service helps study the structure and function of sugars and glycoconjugates and the development of new biological drugs for major diseases.
Fig.1 Comparison of natural glycoconjugates and synthetic glycoconjugates. (Zhang, 2018)
CD BioGlyco provides efficient and time-saving carbohydrate synthesis services, and the synthetic carbohydrate can be modified and labeled according to the needs of customers.
Our solution can challenge the synthesis of the complex structures of glycolipid compounds, and advanced detection technology will be used to ensure the homogeneity of products.
CD BioGlyco offers three different glycopeptides synthesis strategies with their characteristic. Customers can choose different synthesis schemes according to their project needs.
Our chemoenzymatic and synthesis scheme is a highly efficient emerging method, which greatly supplements and expands the chemical method of constructing homogeneous glycoproteins.
We can prepare conjugates with glycans provided by customers or synthesized by us, and the synthesized glycoconjugates will undergo strict quality analysis.
CD BioGlyco has established chemical and biocatalytic synthesis strategies for the service of custom glycoside synthesis, providing customers with scientific assistance in the research of new drugs and materials.
CD BioGlyco is able to synthesize a wide range of glycosyl donors according to customer requirements, and we have a strict testing system to ensure the quality and purity of our products.
CD BioGlyco has accumulated a lot of successful experience in the custom synthesis of thioglycosides by chemical and enzymatic methods, which provides the basis for our satisfactory service.
CD BioGlyco has established strategies combining chemical synthesis and enzyme-catalyzed reactions to provide customers with the synthesis of different types of phosphatidylinositol with clear structure and high purity.
Cyclodextrin has multiple functions such as improving the bioavailability of drugs. CD BioGlyco provides customers with customized synthesis services of cyclodextrin and cyclodextrin polymers.
CD BioGlyco specializes in the efficient synthesis of rhamnolipids through different routes and provides customers with high purity products after rigorous quality analysis.
CD BioGlyco is dedicated to the synthesis of sphingolipids using optimal synthesis strategies according to our customers' needs, and to provide scientific assistance to our clients.
CD BioGlyco provides scientific assistance to our customers in terms of synthesizing their desired building blocks through proven chemical synthesis methods and biocatalytic preparation.
CD BioGlyco provides manufacturing of carbohydrate-based active pharmaceutical ingredients (APIs), carbohydrate-based drug delivery systems and carbohydrate conjugates for receptor targeting.
CD BioGlyco has many years of experience in the field of custom synthesis. We have a professional technical team to provide guidance for customers' projects, and tailor synthesis schemes according to needs. We hope to start the exploration of glycobiology with you. If you are interested in our services, please contact us for more detailed information.