CD BioGlyco is experienced in the development of Glycosphingolipid (GSL) Inhibitors. GSL has important biological functions such as maintaining the stability of the plasma membrane, mediating cell recognition and adhesion, regulating signal transduction, etc. Specific GSLs are found to be aberrantly expressed in many tumor diseases and involved in related molecular mechanisms. The development of GSL inhibitors is one of the ways to study its physiological function and so on. The advantage of receptor analogs is that they should be selective for specific enzymes. It has also become one of the directions for inhibitor development. We provide receptor analog-based GSL inhibitor development services.
Fig.1 Process for receptor analog-based GSL inhibitor development. (CD BioGlyco)
Technology: Synthesis of ceramide analogs
Journal: Tetrahedron: Asymmetry
Results: In the present study, several iminosugars bearing two or three alkyl chains were synthesized. These compounds are ceramide mimics and have some inhibitory effect on GCS. The present study also examined the effect of the position and length of the alkyl chains on the inhibitory effect of GCS. The results showed that the addition of a second alkyl chain did not improve their inhibitory activity. The compounds containing two octyl chains (13b, 14b, and 7b) showed the best inhibitory effect.
Fig.2 Inhibitory effect on GCS. (Boucheron, et al., 2005)
At CD BioGlyco, our Glycosylation Inhibitor development services are well established. Our experienced scientists will customize a solution to meet your needs. Feel free to contact us with your needs. We will be happy to help you with all your glycosylation inhibitor development needs.