Application of ¹⁹F-labeled Probes

¹⁹F-labeled probes are probes obtained by labeling a molecule with a fluorine atom. The use of radioisotopes or stable isotopes to label molecules is a common technique used to track and detect the location, activity, and interaction of target molecules within an organism or in a chemical reaction. ¹⁹F-labeled probes are typically one or more fluorine atoms introduced into the molecular structure and the fluorine atoms are in the ¹⁹F isotopic state. The use of ¹⁹F-labeled probes allows the monitoring and detection of the presence and relative abundance of molecules in a sample using techniques such as nuclear magnetic resonance (NMR). Because of the high sensitivity and low background interference of ¹⁹F NMR, ¹⁹F-labeled probes are widely used in drug discovery, biomolecular detection, and bioimaging for research and development of new drugs, exploration of biological processes, and understanding of molecular interactions and metabolic pathways.

High-Throughput Glycan Screening Using ¹⁹F-Labeled Probes at CD BioGlyco

High-throughput screening (HTS) plays a critical role in drug discovery and chemical biology. CD BioGlyco offers high-throughput glycan screening services using ¹⁹F-labeled probes to help you evaluate large numbers of glycan samples quickly and accurately. Our services encompass a diverse range of offerings, including but not limited to:

• Detection of the presence and relative abundance of glycan
  We design ¹⁹F-labeled probes based on specific glycan structures. The presence and relative abundance of specific glycans in the sample are detected and analyzed by binding the glycans to the ¹⁹F label using NMR. Thus, it is possible to determine which glycans in a large mixture of glycans react with the sample to be tested.
• Explore the interactions of glycans with other molecules
  We use ¹⁹F-labeled probes to help you study the interactions between glycans and other molecules, receptors, or enzymes. Monitor the binding of glycans to other molecules by observing changes or movement of the ¹⁹F NMR signal to help you further study their binding affinity, kinetics, and spatial conformation.

Fig.1 Process for high-throughput detection of the presence and relative abundance of glycans using ¹⁹F-labeled probes. (CD BioGlyco)

Applications

• Vaccine research
• Research on the metabolic pathways of glycans
• Building highly sensitive biosensor

Advantages of Us

• Integration of multiple techniques
• Experienced researchers and technicians
• High-grade standard of service

At CD BioGlyco, our services cover the entire process from sample preparation to data analysis, ensuring that you get accurate and reliable high-throughput glycan screening service using ¹⁹F-labeled probes. We offer rapid access to structural and activity evaluation results for a large number of glycan samples, laying a solid foundation for your subsequent research. If you are interested in our services, please feel free to contact us for more information.