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Biological Agent Loaded Glyconanoparticle Formulation Service

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Overview

CD BioGlyco, as a specialized company focusing on glycobiology research, we are committed to loading biologics into glyconanoparticles efficiently and precisely to break through the limitations of traditional drug delivery and open up new possibilities. Our Glyconanoparticle Formulation Services not only enhance the bioavailability and stability of the loaded materials, but also enables targeted delivery, reduce side effects, and provide powerful support for disease treatment.

Targeting Glyconanoparticle Formulation: Enhance Biological Agent Delivery Efficiency

Biological Agent Selection

Based on the professional GlycoNano™ Platform, our company offers a wide range of biological agents according to clients' research needs in different fields, if you can't find the biological agent you need, contact our researchers for biological agent production service.

Nucleic Acid Loaded Glyconanoparticle Formulation Service

Our researchers efficiently load DNA fragments, RNA molecules (e.g., miRNA, mRNA, siRNA, etc.), or other types of nucleic acids into glyconanoparticles. Moreover, we provide specific chemical modification services to improve their stability and biocompatibility.

Peptide Loaded Glyconanoparticle Formulation Service

Utilizing advanced technologies, our researchers load peptide drugs into glyconanoparticles to improve drug stability and bioactivity. According to the needs of the clients, we provide multiple types of peptide synthesis using enzymatic digestion, fermentation, genetic engineering, liquid phase peptide synthesis (LPPS), and solid phase peptide synthesis (SPPS).

Antibody Loaded Glyconanoparticle Formulation Service

Our company provides high-quality antibody-loaded glyconanoparticle formulation services. We precisely load antibody molecules into glyconanoparticles for targeted delivery and long-lasting release of antibodies, providing new solutions for immunotherapy.

Anti-HIV Prodrug Loaded Glyconanoparticle Formulation Service

Our company provides high-level anti-HIV prodrug-loaded glyconanoparticle formulation services. Our researchers use gold nanoparticles and carbohydrates containing anti-HIV prodrug candidates for designing efficient drug delivery systems. Moreover, we offer release site testing, glyconanoparticle characterization, and antiviral activity analysis.

Glycan Antigen Prodrug Loaded Glyconanoparticle Formulation Service

Our company provides high-performance glycan antigen prodrug-loaded glyconanoparticle formulation services such as GalNAc loading and SialylTn and Lewis y loading. Our researchers optimize the loading process and technical parameters to achieve efficient and stable loading.

Glyconanoparticle Synthesis

Our company has a variety of techniques for synthesizing different types of glyconanoparticles, such as

Biological Agent Loading

Our researchers have extensive experience in biological agent loading. We ensure efficient and stable loading by precisely controlling the conditions (e.g. pH, ionic strength, etc.).

Testing

Our lab provides characterization and validation services for loaded glyconanoparticles including evaluation of size, shape, surface charge, loading efficiency, and biocompatibility. Moreover, it also includes their performance in real-world applications, such as cellular uptake efficiency, and gene expression levels.

Workflow

Schematic of biological agent loaded glyconanoparticle formulation. (CD BioGlyco)

Applications

  • Biological agent-loaded glyconanoparticle formulation provides new ideas and methods for vaccine development and improves the immunogenicity and safety of vaccines.
  • Biological agent-loaded glyconanoparticle formulation can be used for targeted delivery of active drug molecules.
  • Biological agent-loaded glyconanoparticle formulation provides new vectors for gene therapy to improve therapeutic efficacy.

Advantages of Us

  • Efficient loading: Our highly trained research team provides efficient loading of biologics to improve drug bioavailability.
  • Targeted delivery: we provide glyconanoparticles with good biocompatibility and targeting properties, enabling precise delivery of drugs.
  • Personalization: We provide personalized formulation services to meet the diverse needs of our clients.
  • Reduced side effects: Reduce systemic distribution of the drug and reduce side effects through targeted delivery and long-acting release.

Publication Data

Technology: Transmission electron microscopy (TEM), Dynamic light scattering method, Agarose gel electrophoresis, Laser Doppler microelectrophoresis

Journal: Pharmaceutics

Published: 2021

IF: 4.9

Results: In this study, researchers developed a mannose-modified cationic lipid nanoparticle (M-NP) to deliver the nucleic acid adjuvant and polycytidylic acid (PIC). Regardless of the molar ratio of the targeting ligand, the M-NP was able to fully load PIC as cargo. No significant changes in live cell density were observed after 24 and 48 h of cell incubation in the presence of PIC/M-NP with different mannose-PEG lipid contents. Nucleic acid adjuvants offer significant advantages in terms of biocompatibility and safety.

Fig.1 PIC/M-NP analysis.Fig.1 Characterization of PIC/M-NP. (Kim, et al., 2021)

Frequently Asked Questions

  • What types of glyconanoparticles does CD BioGlyco offer for drug loading?
    Our company offers many types of nanoparticles such as gold glyconanoparticles, silver glyconanoparticles, magnetic glyconanoparticles, and quantum dot (QD) glyconanoparticles. If you are interested in other types of glyconanoparticles, please feel free to discuss with our experts for your customized solution.
  • What are the quality control test metrics included?
    • Appearance
    • Encapsulation efficiency
    • Integrity of encapsulated biologics
    • Final concentration
    • Particle size
    • Zeta potential
    • Polydispersity Index (PDI)
    • pH
    • Endotoxin

Combining molecular synthesis and nanoscience, CD BioGlyco provides biological agent-loaded glyconanoparticle formulation services to clients around the world. Whatever type of biological agents you want to develop for glyconanoparticle formulation, We provide you with the most satisfactory solutions. Feel free to contact us.

Reference

  1. Kim, D.; et al. Lipid nanoparticle-mediated lymphatic delivery of immunostimulatory nucleic acids. Pharmaceutics. 2021, 13(4): 490.
This service is for Research Use Only, not intended for any clinical use.
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Platforms
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Featured Products
Nucleic Acid Drug Delivery Products
GalNAc-L96 intermediate, T1 (Cat#: X24-11-YM010) GalNAc-L96 intermediate, T2 (Cat#: X24-11-YM011) GalNAc-L96 intermediate, T3 (Cat#: X24-11-YM012) GalNAc-L96 intermediate, T4-Amine (Cat#: X24-11-YM014) Tri-GalNAc(OAc)3 Cbz (Cat#: X24-11-YM015) Tri-GalNAc(OAc)3 (Cat#: X24-11-YM016) Tri-GalNAc(OAc)3 TFA (Cat#: X24-11-YM017) GalNAc-L96-OH (Cat#: X24-11-YM018) GalNAc-L96-TEA (Cat#: X24-11-YM019)
Hots Products
N-Glycan
Neu5Gcα(2-6)N-Glycan (Cat#: X23-03-YW036) A2G2 N-Glycan (Cat#: X23-03-YW037) A2G2S2 N-Glycan (Cat#: X23-03-YW038) A2 N-Glycan (Cat#: X23-03-YW039) A2[6]G1 N-Glycan (Cat#: X23-03-YW040) M3 N-Glycan (Cat#: X23-03-YW041) A2[3]G2S1 N-Glycan (Cat#: X23-03-YW042)
O-Glycan
Core 2 O-glycan, Ser-Fmoc linked (Cat#: X23-10-YW178) Core 2 O-glycan, Thr-Fmoc linked (Cat#: X23-10-YW179) Core 3 O-glycan, Ser-Fmoc linked (Cat#: X23-10-YW180) Core 3 O-glycan, Thr-Fmoc linked (Cat#: X23-10-YW181) Core 4 O-glycan, Ser-Fmoc linked (Cat#: X23-10-YW182) T antigen O-glycan, Ser-Fmoc linked (Cat#: X23-10-YW192) T antigen O-glycan, Thr-Fmoc linked (Cat#: X23-10-YW193) Tn antigen O-glycan, Ser-Fmoc linked (Cat#: X23-10-YW194)
Blood Group and Lewis Antigen
Blood group A trisaccharide (Cat#: XCO0060Q) Blood group B trisaccharide (Cat#: XCO0068Q) Blood group H disaccharide (Cat#: XCO0074Q) Lewis A trisaccharide (Cat#: XCO0079Q) 3'-Sulfated lewis A (Cat#: XCO0080Q) Lewis B tetrasaccharide (Cat#: XCO0083Q) Lewis X trisaccharide (Cat#: XCO0085Q) Lewis Y tetrasaccharide (Cat#: XCO0088Q)
Human Milk Oligosaccharides (HMOs)
Lacto-N-biose (Cat#: XCO0089Q) 2'-Fucosyllactose (Cat#: XCO0091Q) 3-Fucosyllactose (Cat#: XCO0092Q) Lactodifucotetraose (Cat#: XCO0093Q) Lacto-N-triose I (Cat#: XCO0094Q) 3'-Sialyllactose sodium salt (Cat#: XCO0096Q) 6'-Sialyllactose sodium salt (Cat#: XCO0098Q) 3'-Sialyl-3-fucosyllactose (Cat#: XCO0100Q)
Glycosaminoglycans
Heparin amine, MW 27 kDa (Cat#: X22-09-ZQ478) FITC-heparin, MW 27 kDa (Cat#: X22-09-ZQ480) TRITC-heparin, MW 27 kDa (Cat#: X22-09-ZQ481) Biotin-heparin-FITC, MW 18 kDa (Cat#: X22-09-ZQ482) Chondroitin sulfate (dp4) (Cat#: X22-11-ZQ598) Dermatan sulfate (dp12) (Cat#: X22-11-ZQ611) Heparin disaccharide I-A (Cat#: X22-11-ZQ662) Chondroitine sulfate (Cat#: X23-04-XQ1118)
Carbohydrate Conjugates
GalNAcβ(1-4)GlcNAcβ-Sp3-Biotin (Cat#: X22-12-ZQ005) GalNAcβ(1-4)GlcNAcβ-Sp3-PAA-Biotin (Cat#: X22-12-ZQ006) GalNAcβ(1-4)GlcNAcβ-Sp3-PAA-FITC (Cat#: X22-12-ZQ007) GalNAcβ(1-4)GlcNAcβ-Sp3-PAA (Cat#: X22-12-ZQ008) Glcβ(1-4)GalNAcα-Sp3-Biotin (Cat#: X22-12-ZQ037) Glcβ(1-4)GalNAcα-Sp3-PAA-Biotin (Cat#: X22-12-ZQ038) Glcβ(1-4)GalNAcα-Sp3-PAA-FITC (Cat#: X22-12-ZQ039) Glcβ(1-4)GalNAcα-Sp3-PAA (Cat#: X22-12-ZQ040)
Glycolipids
GlcCer (d18:1/8:0) (Cat#: X23-11-ZQ101) GalCer (d18:1/16:0) (Cat#: X23-11-ZQ112) LacCer (d18:1/8:0) (Cat#: X23-11-ZQ118) Lc3Cer (d18:1/8:0) (Cat#: X23-11-ZQ131) Lc4Cer (d18:1/12:0) (Cat#: X23-11-ZQ146) Sialyl-Lc4Cer (d18:1/18:0) (Cat#: X23-11-ZQ162) Lewis a Cer (d18:1/16:0) (Cat#: X23-11-ZQ175) nLc4Cer (d18:1/18:0) (Cat#: X23-11-ZQ190)
Cyclodextrin
Methyl-γ-cyclodextrin (DS 12) (Cat#: X23-11-YM119) Carboxymethyl-ɑ-cyclodextrin sodium salt (Cat#: X23-11-B003) Carboxymethyl-γ-cyclodextrin sodium salt (Cat#: X23-11-B004) Succinyl-ɑ-cyclodextrin (Cat#: X23-11-B005) Succinyl-γ-cyclodextrin (Cat#: X23-11-B006) ɑ-Cyclodextrin sulfate sodium salt (Cat#: X23-11-B007) β-Cyclodextrin sulfate sodium salt (Cat#: X23-11-B008) γ-Cyclodextrin sulfate sodium salt (Cat#: X23-11-B009)
Dextran
Lysine-dextran, MW 4 kDa (Cat#: X22-09-ZQ273) Phenyl-dextran, MW 150 kDa (Cat#: X22-09-ZQ279) FITC-Q-dextran, MW 10 kDa (Cat#: X22-09-ZQ280) FITC-lysine-dextran, MW 10 kDa (Cat#: X22-09-ZQ283) TRITC-lysine-dextran, MW 10 kDa (Cat#: X22-09-ZQ287) FITC-dextran sulfate, MW 10 kDa (Cat#: X22-09-ZQ291) Dextran amine, MW 20 kDa (Cat#: X22-09-ZQ377) TRITC-dextran, MW 40 kDa (Cat#: X22-09-ZQ383) Biotin-dextran-FITC, MW 20 kDa (Cat#: X22-09-ZQ389)
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