At present, the structure and biological functions of glycosaminoglycans are being extensively studied, and the basis of these analyses is to obtain high-purity glycosaminoglycans. CD BioGlyco has a variety of advanced technology platforms and analysis tools that can help customers study glycosaminoglycans in depth. We have confidence to be your essential research assistant in the field of glycobiology.
Glycosaminoglycan, once called mucopolysaccharide, is mainly found in the connective tissues of higher animals and plants. Glycosaminoglycan (GAG) is a large linear polysaccharide composed of repeating disaccharide units. Its main configuration contains amino sugars (GlcNAc or GalNAc) and uronic acid (glucuronic acid and/or iduronic acid). GAG can be divided into two subgroups: (a) glucosaminoglycans including hyaluronic acid (HA), keratan sulfate (KS), heparan sulfate (HS) and heparin; (b) galactosaminoglycans, which include chondroitin and dermatan sulfate (CS/DS). Except for KS and HA, all GAGs are linked to their parent proteins via xylose-galactose-galactose-glucuronic acid core tetrasaccharide (GlcAb1-3Galb1-3Galb1-4Xylb1-O-Ser).
GAG accounts for a significant portion of glycoconjugates in cell membranes and the extracellular matrix of almost mammalian tissues. Their ability to bind and change protein-protein interactions or enzyme activity significantly affects our understanding of many biological processes, including cell proliferation, differentiation, wound infection and healing. It is also an important cofactor for a variety of cell behaviors.
Fig 1. Monosaccharides in GAG (Valcarcel, J.; et al. 2017)
We provide services to isolate and purify high-quality GAG from various samples such as cells or tissues and can perform subsequent GAG profiling as needed. The separation service process provided by CD BioGlyco is as follows.
CD BioGlyco has a lot of successful experience in the separation and profiling of glycosaminoglycans, and our services have helped customers from all over the world, the efficient services and accurate results have gained a good reputation worldwide for our company.
Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.