Hypromellose Acetate Succinate Analysis Service
Empowering Excellence: Your Partner for Hypromellose Acetate Succinate (HPMCAS) Analysis
HPMCAS is a soluble polymer synthesized from hypromellose and acetyl succinate, which is commonly used as one of the excipients in the pharmaceutical field. HPMCAS has good biocompatibility and solubility, and it plays an essential role in the preparation of solid dispersions, controlled-release drug formulations, and drug coating. CD BioGlyco provides an all-encompassing Pharmaceutical Excipient Analysis Service to our esteemed clients, harnessing cutting-edge technology and unparalleled expertise in the field to bolster your research endeavors in drug discovery and development. Our HPMCAS analysis services encompass a wide range of options, including but not limited to the following.
- Chemical composition analysis
Our specialists assist in identifying the composition and quantity of impurities and additives in HPMCAS using mass spectrometry (MS) techniques including liquid chromatography-MS (LC-MS) and gas chromatography-MS (GC-MS). - Physical property analysis
- We use advanced methods such as thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC) to analyze and study the thermal properties of HPMCAS, such as thermal stability, thermal decomposition temperature, and glass transition temperature.
- We conduct solubility experiments to assess the solubility of HPMCAS in various solvents for pharmaceutical formulations. This helps in determining its solubility in different solvent systems.
- We analyze the rheological properties of HPMCAS utilizing rheological analysis, including viscosity, rheological profile, rheological index, etc., which is particularly suitable for liquid or semi-solid samples.
- HPMCAS and drug compatibility
We provide compatibility analysis services to assist in evaluating the interaction between HPMCAS and drugs, aiding in determining potential chemical reactions, incompatibilities, and impacts on formulation stability and performance.

Publication
Technology: Scanning electron microscope (SEM), Raman mapping
Journal: ADMET and DMPK
IF: 2.16
Published: 2023
Results: This article examines the use of an experimental grade of HPMCAS in a hot-melt extruded amorphous solid dispersion. The authors analyzed the mixing properties of HPMCAS at elevated temperatures by observing the hot-melt extrusion process and the solid dispersion transition of HPMCAS at different processing temperatures using a Raman mapping technique. They also conducted dissolution and permeation experiments to investigate the differences in properties between crystalline indomethacin and solid dispersion during dissolution and permeation. The study ultimately concluded that HPMCAS facilitated the hot-melt extrusion (HME) process at lower temperatures and improved the dissolution and permeation properties of indomethacin.
Applications
- The analytical techniques of HPMCAS are used in the field of materials science to study its physical, thermal, and mechanical properties.
- The analytical technique of HPMCAS is used in the food research industry to analyze the physicochemical properties of the products.
- The application areas of HPMCAS in cosmetics include emulsions, skin care products, and color cosmetics, and its analytical techniques can be used to evaluate its properties such as solubility, stability, and compatibility in cosmetics.

Advantages
- Versatility: Our analytical technology can be used to evaluate its performance in a wide range of applications such as pharmaceutical formulations, cosmetics, coatings, and adhesives.
- Rich analytical methods: In various application scenarios, a range of analytical methods are employed to characterize HPMCAS.
- Reliability: Our validated and standardized analytical methods ensure the reliability and reproducibility of results, facilitating stability and quality control of the analytical process.
By partnering with CD BioGlyco, you can trust that your research efforts will be supported by thorough and precise HPMCAS analysis services, ultimately contributing to the advancement of new drugs. If you are interested in our service, please feel free to contact us.
Reference
- Tanaka, H.; et al. Dissolution-permeation of a hot-melt extruded amorphous solid dispersion comprising an experimental grade of HPMCAS. ADMET and DMPK. 2023, 11(3): 373-385.
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