Gentamicin and Prednisolone Acetate Ophthalmic Ointment Analysis Service

Gentamicin and Prednisolone Acetate Ophthalmic Ointment Analysis Service

Analysis of Gentamicin and Prednisolone Acetate Ophthalmic Ointment to Help the Anti-inflammatory Research

Prednisolone acetate, a synthetic glucocorticoid, acts as an anti-inflammatory and immunomodulating agent by binding to intracellular glucocorticoid receptors. This binding initiates the transcription of glucocorticoid-responsive genes, inhibiting phospholipase A2 and blocking the release of inflammatory mediators. Additionally, it induces cell differentiation, and apoptosis in tumor cells, and reduces circulating lymphocytes. Gentamicin, a bactericidal aminoglycoside, is effective against a broad spectrum of bacteria. Co-administration with other antibacterials, particularly beta-lactams, enhances its efficacy, though it is associated with nephrotoxicity and ototoxicity. CD BioGlyco offers a specialized gentamicin and prednisolone acetate ophthalmic ointment analysis service for the field of Pharmaceutical Analysis, ensuring precise evaluation of this pharmaceutical formulation. Our comprehensive analysis covers various aspects, including identification tests, content determination, impurity profiling, and specific tests.

Fig.1 The structure of gentamicin and prednisolone acetate (CD BioGlyco)Fig.1 The structure of gentamicin and prednisolone acetate (CD BioGlyco)

We take pride in our commitment to technological excellence, providing clients with the assurance that their pharmaceutical products undergo thorough scrutiny using cutting-edge methodologies. Our identification tests utilize thin-layer chromatography for accurate results. The gentamicin assay employs the antibiotics-microbial assay method, ensuring reliable quantification. For prednisolone acetate, we employ chromatography, especially chiral liquid chromatography (CL), for precise assay measurements. Additionally, our specific tests include a sterility test, ensuring the safety and quality of the ophthalmic ointment. Moreover, we also provide more than 90 Pharmaceutical and Biological Analysis services. Rely on CD BioGlyco for thorough and dependable pharmaceutical analysis services.

Fig.2 The content of gentamicin and prednisolone acetate ophthalmic ointment analysis. (CD BioGlyco)Fig.2 The content of gentamicin and prednisolone acetate ophthalmic ointment analysis. (CD BioGlyco)

Publication Data

Technology: Anti-inflammatory, Pyrazole derivatives, Benzimidazole derivativesIndole derivatives, Pyrimidine derivatives, Clinical trials

Journal: European Journal of Medicinal Chemistry

IF: 6.7

Published: 2020

Results: Inflammation is a vital immune response to cell or tissue damage, triggered by various stimuli such as injuries or infections. It serves as a protective mechanism necessary for the body's healing and infection reduction. The process involves the production of pro-inflammatory mediators, recruitment of immune cells, and tissue destruction, leading to redness, heat, pain, and swelling. Interleukin-1β (IL-1β) is a key mediator, inducing various responses in the acute phase. Prednisolone acetate is a corticosteroid medication known for its potent anti-inflammatory properties. It works by inhibiting the release of inflammatory mediators and suppressing the activity of immune cells involved in the inflammatory response.

Fig.3 Inflammatory pathway and different key inhibitors of inflammation. (Sharma, et al., 2020)Fig.3 Inflammatory pathway and different key inhibitors of inflammation. (Sharma, et al., 2020)

Applications

  • Our identification tests can be used to confirm the presence of specific components in the ointment, ensuring the correct formulation.
  • Our gentamicin assay can be used to quantify the concentration of gentamicin ensuring its effectiveness against bacterial infections.
  • Our prednisolone acetate assay can be used to determine the concentration of prednisolone acetate ensuring its adherence to specified levels for anti-inflammatory action.
  • Our specific tests can be used to ensure the absence of contaminants, confirming the ointment's purity and safety for ocular use.

At CD BioGlyco, leveraging advanced analytical techniques and a proficient team, we guarantee accurate results for quality assurance and compliance with regulatory standards. Trust CD BioGlyco for reliable analysis services, contact us for more information about our service.

Reference

  1. Sharma, S.; et al. Recent advancements in the development of heterocyclic anti-inflammatory agents. European Journal of Medicinal Chemistry. 2020, 200: 112438.
This service is for Research Use Only, not intended for any clinical use.

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