Various malignant biological behaviors of cancer cells are inseparable from the resistance to cell death. Clinically, tumor recurrence and chemoradiotherapy resistance are also due to cancer cells getting rid of the regulation of cell death. Cells are mainly regulated by mechanisms such as apoptosis, autophagy, and ferroptosis. Glucose metabolism is involved in multiple steps in the regulation of cancer cell death. Therefore, studying the effect of glucose metabolism reprogramming on cell death has accelerated the development of glucose metabolism-targeted therapeutic strategies. CD BioGlyco can provide an analysis of the role of glucose metabolism reprogramming in apoptosis, autophagy, and ferroptosis based on the MOPCGM platform.

Fig. 1 Schematic illustration showing the involvement of glucose metabolism and ferroptosis (Yao X, et al., 2021)

What We Do

• Analysis of the relationship between glucose metabolism reprogramming and apoptosis

Reduced apoptotic capacity is one of the key features in tumor progression, and the malignant phenotype of tumor cells is related to their apoptotic properties. At present, some studies have shown that metabolites of apoptotic cells can affect the metabolic reprogramming of cancer cells, and some factors involved in regulating glucose metabolism mediate the anoikis of cancer cells, but the specific molecular mechanism is still unclear. Therefore, we advance this field by analyzing the relationship between apoptosis and reprogramming of glucose metabolism.

The specific services we can provide are as follows, including but not limited to:

• Metabolomic analysis of apoptotic cell releases
• Analysis of the effects of metabolites released by apoptotic cells on the expression of genes related to glucose metabolism
• Analysis of the effects of glucose metabolism-related enzymes on apoptosis signaling

• Analysis of the relationship between glucose metabolism reprogramming and autophagy

Autophagy is the process by which cells degrade under stress. Autophagy helps cells maintain homeostasis and resist cell death under pathophysiological conditions. The current research results show that autophagy has a regulatory effect on cancer glucose metabolism. Therefore, studying the effect of autophagy on the reprogramming of glucose metabolism can reveal the specific mechanism of autophagy on tumors.

The specific analysis services we can provide are as follows:

• Analysis of the effects of autophagy on glucose uptake and utilization
• Analysis of the regulatory effect of autophagy on glycolysis-related enzymes
• Analysis of the effect of mitophagy on the tricarboxylic acid cycle

• Analysis of the relationship between ferroptosis and reprogramming of glucose metabolism

Ferroptosis is an emerging cell death pathway. With the continuous development of ferroptosis research, it has been found that ferroptosis is associated with various cellular metabolic pathways, and many cancers therapeutic drugs have also demonstrated ferroptosis-promoting activity. Therefore, studying the relationship between ferroptosis and the reprogramming of glucose metabolism is of great significance for finding new cancer therapeutic targets and understanding the mechanism of ferroptosis.

We can provide the following specific services, including but not limited to:

• Analysis of the effects of regulating the tricarboxylic acid cycle on ferroptosis
• Analysis of the regulation of tricarboxylic acid cycle-related enzymes on ferroptosis
• Analysis of the effects of tricarboxylic acid cycle metabolites on ferroptosis
• Analysis of the effects of the pentose phosphate pathway on ferroptosis

Our Advantages

• We are able to provide comprehensive analytical services for the relationship between glucose metabolism and cell death.
• We are able to grasp the latest research results in the field of glucose metabolism and cell death for the first time to meet the innovative needs of customers.

Applications

Our services can support the following applications, including but not limited to:

• Development of a bidirectional interventional therapeutic strategy for autophagy and glucose metabolism reprogramming.
• To explore therapeutic strategies to block the reprogramming of glucose metabolism in cancer-causing ferroptosis sensitization.
• Searching for molecular targets for ferroptosis-based cancer therapy.

CD BioGlyco can help customers solve the problems in the research related to glucose metabolism reprogramming and cell death, and help customers understand the role of glucose metabolism reprogramming in the process of cell death. Our experienced teams of scientists, researchers, and technicians provide a fast turnaround, and high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.

Reference:

1. Yao X, et al. Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells. Adv Sci (Weinh). 2021 Nov; 8 (22): e2100997.