Custom Complex N-linked Oligosaccharides Synthesis

Custom Complex N-linked Oligosaccharides Synthesis

CD BioGlyco has extensive experience in the synthesis of custom complex N-linked Oligosaccharides. The unique technology platforms and professional researchers of our company ensure that we offer high-efficient services at a competitive price for our clients. We have the confidence to help our clients accelerate their research on glycobiology by reducing project costs and timelines.


N-linked oligosaccharide is characterized by the attachment of glycans to an asparagine side chain of the protein. The glycosylation site of N-linked oligosaccharides is Asn-X-Ser/Thr, where X represents any amino acid except proline. N-linked oligosaccharides have important biological significance, including enhancing solubility and stability of protein, acting as signal molecules in protein folding and transportation, determining the specificity of membrane receptors in cell-to-cell interactions or innate immunity, and changing the properties of hormones and secreted proteins.

The biosynthesis of N-linked glycans occurs through 3 major steps: synthesis of dolichol-linked precursor oligosaccharides, en bloc transfer, and initial trimming of precursor oligosaccharides in the endoplasmic reticulum (ER), and Subsequent processing in the Golgi apparatus. At present, multi-step Chemical or biological synthesis of N-linked oligosaccharides with various structures is the main effective way to obtain N-linked oligosaccharides by artificial strategy, which is of great significance to study the relationship between saccharides and disease.

Different stages of N-glycan complexity. Fig.1 Different stages of N-glycan complexity. (Fisher, 2016)


Equipped with advanced technology platforms and professional research teams in the field of glycobiology, CD BioGlyco has established effective chemical or chemoenzymatic methods to synthesize high-purity N-linked oligosaccharides for our customers. The services we provide include but are not limited to:

  • Characterization and profiling of N-linked oligosaccharides.
  • Synthesis of various N-linked oligosaccharides by effective and concise chemical methods.
  • Synthesis of complex N-linked oligosaccharides through the chemoenzymatic method according to clients’ demands.
  • Various modifications of N-linked oligosaccharides according to customers’ scientific requirements.
  • Purity and quality detection of customized synthesized N-linked oligosaccharides.


  • Research of functional N-linked oligosaccharides
  • Research of interaction between N-linked oligosaccharides and protein
  • Research on the relationship between N-linked oligosaccharides and diseases

Advantages of us

  • Extensive experience in complex N-linked oligosaccharides synthesis
  • Optimized experimental conditions
  • Highly flexible multi-step synthesis method.
  • Products with high yield and high stereoselectivity

CD BioGlyco has successfully synthesized a variety of complex N-linked oligosaccharides through multi-step synthesis. We have the confidence to offer custom complex types of N-glycans synthesis service with high quality for our clients. If you are interested in our services, please contact us for more detailed information.


  1. Mitra, N.; et al. N-linked oligosaccharides as outfitters for glycoprotein folding, form and function. Trends in Biochemical Sciences. 2006, 31(3):156-163.
  2. Fisher, P.; Ungar, D. Bridging the gap between glycosylation and vesicle traffic. Frontiers in cell and developmental biology. 2016, 4:15.
This service is for Research Use Only, not intended for any clinical use.

About Us

CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.

Contact Us

Copyright © CD BioGlyco. All rights reserved.