Glycosaminoglycan (GAG) is a class of highly sulfated, negatively charged and dispersed linear polysaccharides, usually composed of a backbone of repeating disaccharide units formed by uronic acid and glycosamine residue. GAG includes heparin (HP), heparan sulfate (HS), chondroitin sulfate (CS), dermatan sulfate (DS), hyaluronic acid (HA) and keratan sulfate (KS). GAG affects various biological functions, such as cell migration, cell adhesion, growth factor signaling, collagen fiber formation, and immune cell functions, etc.
We can provide highly selective GAG separation/purification technology and highly sensitive, informative GAG structural analysis to obtain structural information, such as molecular weight, monosaccharide composition, Kdo linkage analysis, and composition of disaccharide block. GAG has a variety of biological functions and plays an important role in many different diseases. The overall analysis of GAG can enhance a further understanding of its biological functions and also help develop the structure-activity relationship of these important biopolymers.
Fig 1. Schematic representation of glycosaminoglycan chains (Merida-de-Barros, D.A.; et al. 2018)
We can separate and purify GAG from various samples (cells or tissues), and provide customers with high-purity GAG samples by combining different kinds of purification methods.
CD BioGlyco has provided glycosaminoglycan related services to researchers, and our quality and efficiency have been confirmed by numerous clients. We hope to support your glycobiology research.
Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.