Diagnostic Agent Loaded Glyconanoparticle Formulation Service
Overview
In the field of biomedical research and diagnosis, glyconanoparticles, as a new carrier technology, have shown unprecedented potential. CD BioGlyco focuses on developing and optimizing the formulation services of glyconanoparticles loaded with diagnostic preparations. We are committed to using advanced technologies to efficiently and safely load magnetic nanoparticles, fluorescent probes, imaging contrast agents, and radioactive isotopes into glyconanoparticles to meet the needs for accurate diagnosis in different application scenarios. Relying on the support of the GlycoNano™ Platform, our lab provides satisfactory Glyconanoparticle Formulation services.
Our Diagnostic Agent Loaded Glyconanoparticle Formulation Holds Unlimited Potential
Magnetic Loaded Glyconanoparticle Formulation
Taking advantage of the excellent biocompatibility and stability of glyconanoparticles, our researchers provide efficient magnetic-loaded glyconanoparticle formulation services such as iron oxide, core-shell silica superparamagnetic, and hypericin-entrapped loading.
Fluorescent Probe Loaded Glyconanoparticle Formulation
Our company achieves visual tracking of intracellular molecules by precisely regulating the combination of fluorescent probes and glyconanoparticles, providing intuitive and highly sensitive detection methods for cell biology research and clinical pathology diagnosis.
Imaging Contrast Agent Loaded Glyconanoparticle Formulation
Our high-quality imaging contrast agent-loaded glyconanoparticle formulations such as hyaluronic acid conjugated quantum dot-loading, silicon quantum dot loading, and CdSe-ZnS quantum dots loading.
Radioisotope Loaded Glyconanoparticle Formulation
Combining isotope labeling and glyconanoscience, Our company provides professional radioisotope-loaded glyconanoparticle formulation services such as technetium-99m-labeling, 68Ga-labeling, and 64Cu-radiolabeled labeling.
Customized Synthesis of Glyconanoparticles
According to the specific needs of clients in different fields, our well-trained team of talents customizes the synthesis of magnetic glyconanoparticles of different sizes, shapes, and surface modifications for clients to ensure that the products meet your research or application needs. The preparation methods we commonly use include co-precipitation, high-temperature decomposition, hydrothermal synthesis, microemulsion, etc.
Surface Modification
Our lab provides professional surface modification services. Our researchers use chemical methods to combine organic small molecule compounds with the particle surface to construct more active sites. Commonly used compounds include chitosan, glucose, starch, etc.
Performance Characterization and Optimization
Our company uses advanced characterization techniques to conduct detailed performance evaluations of synthesized glyconanoparticles and makes necessary optimizations based on the evaluation results. Our researchers provide multiple index evaluations including but not limited to nanoparticle morphology, size, hydrodynamic size, ζ-potential, optical properties, dye loading efficiency, and fluorescence.
Workflow
Applications
- Diagnostic agent-loaded glyconanoparticle formulation provides powerful tools for research in areas such as cell biology and molecular biology.
- Diagnostic agent-loaded glyconanoparticle formulation improves the accuracy of medical imaging diagnosis and provides support for the early detection of diseases such as tumors and cardiovascular diseases.
- Diagnostic agent-loaded glyconanoparticle formulation plays an important role in immobilized enzymes, magnetically controlled intravascular magnetic microsphere embolization, affinity purification, and tissue engineering.
Advantages of Us
- Performance testing: Our company provides detailed performance tests on products, including stability, biocompatibility, loading efficiency, and targeting ability.
- Efficient and safe: Our researchers provide high-quality optimized loading strategies to ensure efficient loading and biosafety of diagnostic preparations.
- Our company has an efficient data analysis team to help clients analyze data images and provide detailed analysis reports.
Publication Data
Technology: In vivo imaging system (IVIS) spectrum, Scanning electron microscope (SEM), Flow cytometry binding assay, Toxicity studies, Microplate reader
Journal: Pharmaceutics
Published: 2023
IF: 4.9
Results: In this study, researchers synthesized poly(lactic-co-glycolic acid) (PLGA)-chitosan nanoparticles and loaded them with two near-infrared (NIR) fluorescent dyes, IR-780 iodide and Nile blue (NB). The researchers imaged the PLGA-IR-780-NB loaded nanoparticles using an IVIS visualizer. The researchers studied the weak absorption peaks of the two dyes in the blue light region and determined the optimal conditions for fluorescence excitation. PLGA-chitosan nanoparticles loaded with NIR fluorescent dyes exhibit significant phototherapy effects and imaging properties in human epidermal growth factor receptor 2 (HER2)-positive tumor cells.
Fig.1 Nanoparticle analysis. (Kotelnikova, et al., 2023)
Frequently Asked Questions
- What is the principle of MRI (magnetic resonance imaging) contrast agent imaging?
Contrast agents are used to shorten the resonance time of different tissues in an imaged organism under the action of an external magnetic field, enhance the difference in contrast signals, and improve imaging contrast and clarity. It effectively detects the imaging difference between normal tissue and diseased tissue and displays the functional status of organs or tissues in the body. According to the research needs of clients, we provide high-sensitivity imaging contrast agents. - What physical and chemical methods can be used to synthesize glyconanoparticles?
- Physical approaches: Vapor condensation, laser ablation, sputtering, and ball milling.
- Chemical approaches: Co-precipitation or chemical reduction, solvothermal method, thermal decomposition, micro-emulsion, and green synthesis.
CD BioGlyco provides unparalleled diagnostic agent-loaded glyconanoparticle formulation services based on our client's research needs. Please feel free to contact us to explore the infinite possibilities of glyconanoparticle technology.
Reference
- Kotelnikova, P.A.; et al. Targeted PLGA-chitosan nanoparticles for NIR-triggered phototherapy and imaging of HER2-positive tumors. Pharmaceutics. 2023, 16(1): 9.
