Overview

Combining glycobiology and nanomaterials, CD BioGlyco provides specialized Glyconanotechnology-based Biosensor Development services. Particularly in pathogenic bacteria and toxin detection, our sensors utilize the unique properties of glyconanotechnology to efficiently and sensitively identify and capture target pathogens. Based on the comprehensive GlycoNano™ Platform, we offer highly accurate and sensitive pathogenic bacteria and toxin sensor development services.

Your Trusted Pathogenic Bacteria and Toxin Sensor Development Partner

Carbohydrate Selection

• Due to the strong selective recognition affinity of pathogenic bacterial surface lectins for carbohydrates, it is possible to obtain better results in isolating and enriching pathogenic bacteria using sugar-based modified magnetic nanoparticles or microspheres. Our company offers these types of carbohydrate-based pathogenic bacteria and toxin sensor development below.
• Our lab commonly uses testing methods that include scanning electron microscope (SEM), colorimetry, mass spectrometry (MS), visible spectrum, microarray, fluorescence, quartz crystal microbalance (QCM), square wave voltammetry (SWV), electrochemical impedance spectroscopy (EIS), surface plasmon resonance (SPR), and confocal fluorescence microscopy (CLSM) imaging.

  Carbohydrates	Assay	Carbohydrates	Assay
  Galα1-4Galβ	SEM	Glu-polydiacetylene	Colorimetry
  Man/Glu/Lewis a/b/x	MS	Man/sialic acid-polythiophene	Visible spectrum
  Man/Gal-Polymers	Fluorescence	Man/Glu/Fuc	Microarray/Fluorescence
  Man/Glu-poly(p-phenylene)s	Fluorescence	Man	QCM/SWV
  Man-CdS quantum dots	CLSM	Man-Poly(amidoamine)s	CLSM
  Man/Gal	EIS	p-Thiolphenyl aminomannose	SPR
  Lewis a/b-Nanoparticles	CLSM	Man-ConA	QCM/SWV

Sensor Development

For specific pathogenic bacteria and toxins, we offer glyconanobiosensor development services including design, synthesis, testing, and optimization services.

• Our researchers offer microfluidic chip preparation with integrated microelectrodes and design and prepare nanomaterials on the microelectrode surface. We immobilize carbohydrates on its surface to form a carbohydrate-based nanosensing interface.
• To better mimic physiological environments, we offer selective recognition tests and studies of the pathogenic bacteria-sugar interface by EIS.
• We offer testing and evaluation services for the anti-adhesion efficacy of different carbohydrates to optimize biosensors.

Nano-Biosensors for the Detection of Pathogenic Bacteria and Toxin

For the synthesized nano-biosensors, we provide professional pathogenic bacteria and toxin detection services including but not limited to electrochemical, surface-enhanced Raman scattering (SERS), colorimetric, and fluorescence detection. Our company offers a multi-modality-based assay service to help clients screen pathogenic bacteria and toxins quickly and accurately.

Workflow

Applications

• Glyconanotechnology-based pathogenic bacteria and toxin sensor accesses chemical and biological information about life processes at the cellular and molecular levels and understand biological molecules and their structure-function relationships.
• Glyconanotechnology-based pathogenic bacteria and toxin sensors can be used to detect trace amounts of foodborne pathogens.
• Glyconanotechnology-based pathogenic bacteria and toxin sensors can be used both to calculate bacterial/lectin-glycan binding affinity constants and to apply to research areas such as screening of carbohydrate-based anti-adhesion drugs.

Advantages of Us

• The nano biosensors provided by our company have the advantages of sensitivity and time-saving, real-time detection, low operational requirements, low material consumption, and low limit of detection (LOD).
• We offer a wide range of assay modes including single-mode, dual-mode, and multi-mode assays. According to the client's research needs, we provide the most suitable detection program.
• Our nanosensors provide results in a short time and are suitable for rapid testing needs.

Publication Data

Frequently Asked Questions

• What pathogenic bacteria are sensors typically used to detect?
  The sensors offered by our company can be used to detect Salmonella typhimurium, Campylobacter jejuni, Escherichia coli, Listeria monocytogens, Clostridium botulinum, Staphylococcus aureus, Shigella, Vibrio vulnificus, Vibrio cholera, Vibrio parahaemolyticus, Yersinia enterocolitica. Our company offers personalized sensor synthesis services for specific toxins and pathogens.
• What are the advantages of SERS detection?
  SERS is a method based on electromagnetic and chemical enhancement to amplify Raman signals, with the advantages of strong discrimination, fast response, and high sensitivity. In addition, the SERS intensity can be adjusted by changing the composition, surface morphology, and particle size of the nanomaterials.

With advanced nano-processes and a highly trained production team, CD BioGlyco provides our clients around the world with a reassuring glyconanotechnology-based pathogenic bacteria and toxin sensor development service. We have a wide range of carbohydrate resources and assay formats to meet the needs of clients in different studies. Don't hesitate to contact us whenever you need assistance.