In clinical practice, many tumor patients die of distant tumor metastasis, and tumor metastasis is a huge challenge for tumor therapy. It is well known that tumor metastasis is a multi-stage process involving the regulation of multiple factors. Cancer cells have enhanced invasive and migratory abilities after undergoing epithelial-mesenchymal transition, and the epithelial-mesenchymal transition is a complex, multifactorial regulated process. Among them, the reprogramming of glucose metabolism and the epithelial-mesenchymal transition are interacting and interconnected. Cancer stem cells are a group of tumor cells with self-renewal ability. During tumor metastasis, cancer stem cells can colonize distant target organs through blood circulation, adapt to the new environment and eventually form metastases visible to the naked eye. From the process of primary tumor invading normal tissues to cancer cells forming new metastases, the reprogramming of glucose metabolism in cancer cells endows them with the ability to adapt to different environments and promotes tumor invasion and metastasis. CD BioGlyco can reveal the relationship between glucose metabolism reprogramming and tumor invasion and metastasis by analyzing the glucose metabolism characteristics of cancer cells at different stages of tumor metastasis.
Fig. 1 Interplay of glycolysis pathway with epithelial-mesenchymal transition factors (Georgakopoulos-Soares I, et al., 2020)
Glycolysis, tricarboxylic acid cycle, and other glucose metabolism pathways are all involved in the epithelial-mesenchymal transition of cancer cells. Therefore, the relationship between glucose metabolism reprogramming and the epithelial-mesenchymal transition has a broad unknown research space. We are able to provide analytical services for the correlation between glucose metabolism reprogramming and epithelial-mesenchymal transition.
We can provide the following specific services based on the MOPCGM platform, including but not limited to:
In recent years, the heterogeneity and plasticity of glucose metabolism in cancer stem cells have become a research hotspot. By targeting the glucose metabolism process of tumor stem cells, tumor metastasis and recurrence can be effectively blocked. Therefore, by analyzing the role of cancer stem cell glucose metabolism reprogramming in tumor metastasis, we hope to find a therapeutic method that can target cancer stem cells and block tumor metastasis and recurrence from the source.
We can provide the following specific services, including but not limited to:
Analysis of the correlation between the glucose metabolism characteristics of cancer stem cells and specific organ metastasis
Analysis of the relationship between glucose metabolism and invasion and metastasis ability of cancer stem cell subsets
Analysis of the characterization of circulating tumor cells’ glucose metabolism
CD BioGlyco can provide analysis services for the interaction between tumor glucose metabolism reprogramming and tumor cell invasion and metastasis. Our experienced teams of scientists, researchers, and technicians provide a fast turnaround, and high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.