In clinical practice, many tumor patients die of distant tumor metastasis, and tumor metastasis is a huge challenge for tumor therapy. It is well known that tumor metastasis is a multi-stage process involving the regulation of multiple factors. Cancer cells have enhanced invasive and migratory abilities after undergoing epithelial-mesenchymal transition, and the epithelial-mesenchymal transition is a complex, multifactorial regulated process. Among them, the reprogramming of glucose metabolism and the epithelial-mesenchymal transition are interacting and interconnected. Cancer stem cells are a group of tumor cells with self-renewal ability. During tumor metastasis, cancer stem cells can colonize distant target organs through blood circulation, adapt to the new environment and eventually form metastases visible to the naked eye. From the process of primary tumor invading normal tissues to cancer cells forming new metastases, the reprogramming of glucose metabolism in cancer cells endows them with the ability to adapt to different environments and promotes tumor invasion and metastasis. CD BioGlyco can reveal the relationship between glucose metabolism reprogramming and tumor invasion and metastasis by analyzing the glucose metabolism characteristics of cancer cells at different stages of tumor metastasis.

Fig. 1 Interplay of glycolysis pathway with epithelial-mesenchymal transition factors (Georgakopoulos-Soares I, et al., 2020)

What We Do

• Analysis of the relationship between glucose metabolism reprogramming and epithelial-mesenchymal transition

Glycolysis, tricarboxylic acid cycle, and other glucose metabolism pathways are all involved in the epithelial-mesenchymal transition of cancer cells. Therefore, the relationship between glucose metabolism reprogramming and the epithelial-mesenchymal transition has a broad unknown research space. We are able to provide analytical services for the correlation between glucose metabolism reprogramming and epithelial-mesenchymal transition.

We can provide the following specific services based on the MOPCGM platform, including but not limited to:

• Analysis of the effects of glucose metabolism-related enzymes on epithelial-mesenchymal initiation
• Analysis of the effects of glucose metabolism-related enzymes on the expression of epithelial-mesenchymal-related proteins
• Analysis of the effects of epithelial-mesenchymal transition transcription factors on the expression of enzymes related to glucose metabolism
• Analysis of the glucose metabolism pathway of epithelial-mesenchymal transition in different cancer types

• Analysis of the relationship between cancer stem cells glucose metabolism reprogramming and invasion and metastasis

In recent years, the heterogeneity and plasticity of glucose metabolism in cancer stem cells have become a research hotspot. By targeting the glucose metabolism process of tumor stem cells, tumor metastasis and recurrence can be effectively blocked. Therefore, by analyzing the role of cancer stem cell glucose metabolism reprogramming in tumor metastasis, we hope to find a therapeutic method that can target cancer stem cells and block tumor metastasis and recurrence from the source.

We can provide the following specific services, including but not limited to:

Analysis of the correlation between the glucose metabolism characteristics of cancer stem cells and specific organ metastasis

Analysis of the relationship between glucose metabolism and invasion and metastasis ability of cancer stem cell subsets

Analysis of the characterization of circulating tumor cells’ glucose metabolism

Our Advantages

• We have extensive experience in cancer stem cell research.
• Our high-throughput experimental platform can provide pan-cancer stem cell glucose metabolism services.
• We are able to provide analysis services for cancer stem cell subsets.
• We continuously optimize cancer stem cell research technology and are willing to accept challenging projects.

Applications

• Searching for cancer therapeutic targets targeting the epithelial-mesenchymal transition glucose metabolism pathway in cancer cells.
• Development of therapeutics targeting cancer stem cell glucose metabolism pathways to inhibit tumor metastasis.

CD BioGlyco can provide analysis services for the interaction between tumor glucose metabolism reprogramming and tumor cell invasion and metastasis. Our experienced teams of scientists, researchers, and technicians provide a fast turnaround, and high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.

Reference:

1. Georgakopoulos-Soares I, et al. EMT Factors and Metabolic Pathways in Cancer. Front Oncol. 2020 Apr 7; 10: 499.