Custom Glycosyl Donor Synthesis

Combining a systematic and advanced experimental instrumentation platform and innovative researchers, CD BioGlyco provides high-quality custom synthesis services of glycosyl donors to help our clients better understand the mechanisms of glycosylation. Our efficient and reliable services will accelerate your research.

Glycosylation Mechanism

With the emergence of more and more glycosylation methods and new technologies, exploring the effects and parameters important for the reactivity and selectivity of the glycosylation reaction has attracted the attention of researchers, mainly focusing on the effects in the ordinary donor systems. A glycosyl donor is a carbohydrate monosaccharide or oligosaccharide, which will react with an appropriate glycosyl acceptor to form new glycosidic bonds. Traditionally, the donor contains the resulting anomeric carbon of the new glycosidic bond. The resulting reaction is called glycosylation or chemical glycosylation.

A leaving group is required at the anomeric position in a glycosyl donor. The simplest leaving group is the OH group naturally existing in monosaccharides, but it needs to be activated by acid catalysis to act as leaving group. Typical leaving groups are thioalkyl groups, imidates, or halides, but phosphate, acetate, and O-pentenyl groups are also employed. The reactivity of glycosyl donors depends to a large extent on their protecting groups, which result in the classification of these compounds into three types of reactivity: disarming, armed, and super-armed.

A series of common glycosyl donor  types. Fig.1 A series of common glycosyl donor types.

Synthesis Services

CD BioGlyco is proficient in the synthesis of glycosyl donors bearing good leaving groups and modification of glycosyl donors through various methods according to the customers’ needs. The services we can provide include but are not limited to:

  • Synthesis for glycosyl donors of normal sugars:
    • Synthesis of glycosyl donors with acyl protecting groups.
    • Synthesis of glycosyl donors with alkyl protecting groups.
    • Synthesis of β-mannosides through various methods, including heterogeneous system method, 4,6-benzylidene group (pre-activation strategy), and conversion of glucose to mannose.
  • Synthesis for glycosyl donors of unusual sugars:
    • Methods for epimerization.
    • Methods for amino (azido) substitution.
    • Methods for deoxygenation.

Advantages of Us

  • Customer-centric to provide quality service
  • Innovative and rigorous scientific spirit
  • Open, patient, and respectful communication
  • Fast, efficient, and customized service

CD BioGlyco provides high-quality custom synthesis of glycosyl donors to our customers using the optimal synthetic routes and experimental conditions. Our professional technical team will continuously follow the progress of the project and provide real-time guidance to provide rapid and effective solutions to our customers. If you are interested in our service, please feel free to contact us for detailed information.

Reference:

  1. Zhang, F.; et al. Synthesis and applications of a light-fluorous glycosyl donor. J Org Chem. 2009, 20;74(6):2594-7.
This service is for Research Use Only, not intended for any clinical use.

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