Sugar-nucleotides are of great significance in mediating biological processes and the development of carbohydrate drugs. CD BioGlyco has many years of experience in sugar-nucleotides synthesis, and can customize high-quality synthesis services according to customers' research needs. We have confidence to be your essential research assistant in the field of glycobiology.
Structurally, sugar-nucleotides are composed of a sugar or sugar derivative and a nucleoside monophosphate or diphosphate. Sugar-nucleotides are necessary intermediates for carbohydrate metabolism and glycoconjugate biosynthesis. The biosynthesis of glycans and glycoconjugates depends on the activation of monosaccharides as sugar-nucleotides. They are composed of an activated sugar donor that is glycosylated onto a diverse range of acceptors, typified by glycosyltransferase catalyzed processes for the assembly of glycosides and oligo- or polysaccharides.
Sugar-nucleotides and structural analogs can be used as substrates for enzymatic reactions in carbohydrate synthesis, as powerful tools for studying glycoconjugate biosynthesis, and they have the potential as enzyme inhibitors in new therapeutic strategies. Besides, they are also important for the provision of structurally defined homogenous analytical standards.
Therefore, the effective preparation of natural and unnatural sugar-nucleotides is of great significance in both synthetic biology and medicinal chemistry. The synthesis of sugar-nucleotides is more difficult because of many factors: Sugar-nucleotides synthesis can be difficult due to many factors: the low solubility of sugar nucleotides in organic solvents, the presence of polar or charged functional groups, as well as the sensitivity of glycosidic and pyrophosphate bonds to hydrolytic cleavage.
Fig 1. Representative examples of common mammalian sugar-nucleotides (Ahmadipour, S.; et al.)
CD BioGlyco provides a variety of professional sugar-nucleotides synthesis services. Consumers have the option to choose what suits their research plan the most.
CD BioGlyco can customize different experimental programs to meet the different research needs of customs. We have first-class experimental equipment and experienced researchers to provide you with professional sugar-nucleotides synthesis services.
Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.