Sphingolipids have great potential in drug development in the treatment of many diseases such as atherosclerosis. The custom synthesis of sphingolipids has gained considerable attention nowadays. CD BioGlyco supplies the optimal synthesis strategy to provide scientific assistance for customers to explore the function and application of sphingolipids.

Background

Sphingolipids are a class of amphiphilic lipids containing a sphingolipid backbone with a long chain of fatty acids attached to one end and polar alcohol at the other end. Sphingolipids, including gangliosides and sphingomyelin, generally exist in plant and animal membranes, especially in the tissues of the central nervous system. Sphingolipids are of great importance in cell signal regulation, maintenance of membrane functions and integrity, protection of lipoprotein structure and functions, and prevention or promotion of many diseases such as atherosclerosis.

Given the complexity and diversity of sphingolipid structures, these compounds have a variety of biological activities and are intricately involved in many significant metabolic pathways and disease processes. Compounds containing the modification to the sphingosine skeleton are suitable for identifying various biological pathways involving sphingolipid. Researchers have produced a variety of analogues containing fluorescent moiety through different techniques, such as the synthesis of fluorophores linked by hydroxyl or amino groups and the synthesis of fluorophores attached by olefin cross-metathesis.

Fig.1 Chemical structures of the two fluorescent glycosphingolipids (GSLs): 2-NBD-GM2 and 2-NBD-GM1. (Rasmussen, 2008)

Services

CD BioGlyco is proficient at the unequivocal synthesis of sphingolipid using more facile and efficient approaches. we provide the optimal experimental scheme according to the needs of our customers. The services we provide include but are not limited to:

• Modification of the sphingolipid backbone.
• Synthesis of simple bioactive sphingolipids including sphingosine bases and ceramides by stereocontrolled and efficient synthetic routes.
• Synthesis of complex sphingolipids including sphingomyelins, glycosphingolipids, cerebrosides, sulfatides and gangliosides.
• Analysis of sphingolipid bases by gas chromatography and mass spectrometry.

Applications

• Research on the enzymatic metabolism of sphingolipids
• Research on the complete chemical profile of sphingolipids and their anticancer activity
• Research of potential pharmacological targets for the treatment of metabolic disorders

Advantages of Us

• Professional researchers with rich experience
• Optimized scientific scheme design
• Advanced experimental platform
• Strict quality control of products

To help researchers investigate the extensive biological functions of sphingolipid, CD BioGlyco provides optimized sphingolipid synthesis services with high quality in a short time. In addition, all of our synthetic products will go through multiple inspections to ensure high purity. Please feel free to contact us for more detailed information.

References:

1. Dobrzyn, A.; et al. Sphingolipid mediators of cell signaling and metabolism. Lipid Signaling and Metabolism. 2020, 385-411.
2. Rasmussen, J.; Hermetter, A. Chemical synthesis of fluorescent glycero- and sphingolipids. Progress in lipid research. 2008, 47(6):436-460.