Trisaccharides-based Glycomedicine Development

CD BioGlyco has a professional carbohydrate-based glycomedicine development platform with multiple advanced technologies to help customers comprehensively progress in trisaccharides-based glycomedicine development. We expect to become customers' research assistants in the field of glycobiology and glycochemistry.

Trisaccharides and Their Potentially Beneficial Effects.

Trisaccharides are oligosaccharides composed of three monosaccharides with two glycosidic bonds connecting them. Similar to the disaccharides, each glycosidic bond can be formed between any hydroxyl group on the component monosaccharides. Even if all three component sugars are the same (e.g., glucose), different bond combinations (regiochemistry) and stereochemistry (alpha- or beta-) result in trisaccharides that are diastereoisomers with different chemical and physical properties. The major trisaccharides include raffinose, lactosucrose, and melezitose.

Trisaccharides are associated with many potentially beneficial effects. For example, lactosucrose promotes bifidobacterium multiplication, reduces intestinal pH, inhibits the proliferation of pathogenic bacteria, enhances mineral bioavailability and improves the production of short-chain fatty acids. Additionally, the consumption of lactosucrose has also been associated to other potential beneficial effects such as inhibition of body fat accumulation; enhancement of intestinal calcium absorption; prevention of colitis and inflammatory bowel disease; immunoregulatory activity; improvement of amino acid metabolism and anti-allergic activity. Therefore, the development of trisaccharides-based glycomedicine has broad prospects.

Synthesis of trisaccharide of S. aureus type 8 capsular polysaccharide.Fig.1 Synthesis of trisaccharide of S. aureus type 8 capsular polysaccharide. (Zhao, et al., 2020)

Trisaccharides-based Glycomedicine Development Services

CD BioGlyco has professional research teams and various systematic solutions for the development of trisaccharides-based glycomedicine. In addition, extensive experience gives us the ability to extract and synthesize well-defined trisaccharides. Our services include but are not limited to:

  • Analysis of trisaccharide interactions with purified monoclonal antibodies by various biochemical and biophysical techniques to gain insight into the immunological features of trisaccharide antigens, such as epitope recognition patterns, binding affinities, and carbohydrate-antibody interactions.
  • Extraction, design, and chemical synthesis of functional trisaccharides. For example, the extraction of soy oligosaccharides (composed of trisaccharide raffinose) from soybeans, peas, and some other legumes. They may play a role in preventing allergies and can be used to treat galactosemia and lactose intolerance.

Advantages of Us

  • Advanced development technology platforms and professional research teams.
  • Cost-effective customized strategies.
  • Hassle-free services.

CD BioGlyco is committed to research in the field of glycobiology and glycochemistry for many years, providing our customers with unique and high-quality glycomedicine development services according to their needs. If you are interested in our services, please contact us to obtain more information.

Reference:

  1. Zhao, M.; et al. Conjugation of synthetic trisaccharide of Staphylococcus aureus type 8 capsular polysaccharide elicits antibodies recognizing intact bacterium. Frontiers in chemistry. 2020, 8: 258.
This service is for Research Use Only, not intended for any clinical use.

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