Oxidized Regenerated Cellulose Analysis Service

Oxidized Regenerated Cellulose Analysis Service

Clear Insights for Oxidized Regenerated Cellulose (ORC) Analysis

ORC is a slightly off-white knit fabric, usually presented in the form of sterile strips with a faint smell. It is a unique material derived from the oxidation and regeneration of natural cellulose. Its distinctive physical and chemical attributes make it versatile for use in various research including medicine, bioengineering, and filtration. Despite its insolubility in water and dilute acids, it is soluble in dilute alkalis. A thorough understanding of the chemical and biological detection/characterization techniques of ORCs is critical to assess their quality and performance. At CD BioGlyco, we provide Superior Analytical Services for a wide range of pharmaceuticals and biologicals. Among the hundreds of pharmaceuticals and biologicals we provide analysis for, ORC is one of our specialty services. This service includes identifications, impurities, specific tests, instrumental analysis, and biological analysis of ORC.

Fig.1 ORC analysis service. (CD BioGlyco)Fig.1 ORC analysis service. (CD BioGlyco)

  • Identification
    • Evaluation 1: Vigorously agitate the sample fluid, then incorporate water and agitate again. Ensure the resultant solution only exhibits a minimal haze and contains no fibers or foreign materials.
    • Evaluation 2: Leave the solution undisturbed for a duration. Confirm that any previous presence of swollen fibers is no longer discernible.
    • Evaluation 3: Infuse the resultant solution with 3 N hydrochloric acid to engender a flocculent white sediment.
  • Impurity analysis
    • Residue on ignition
    • Limit of nitrogen
    • Limit of formaldehyde
  • Specific tests
    • Sterility tests
    • Loss on drying
  • Instrumental analysis
    • Fourier transform infrared spectroscopy (FTIR): We use FTIR to identify the functional groups and overall chemical structure of ORC. It allows qualitative and quantitative analysis of the chemical composition.
    • Scanning electron microscopy (SEM): SEM is used to study detailed images of the surface morphology of ORC at the micrometer and nanometer scale.
    • X-ray diffraction (XRD): We use XRD to analyze the crystalline structure of ORC, providing information on the arrangement of atoms, and the size and shape of the crystallites.
    • Thermogravimetric analysis (TGA): TGA is utilized to track shifts in physical and chemical attributes relative to escalating temperatures, furnishing data regarding ORC's thermal stability.
  • Biological analysis
    • In vitro hemostatic properties assay: We use thromboelastography (TEG) or thrombin generation test to measure the hemostatic efficacy of ORC. These tests measure the speed, strength, and stability of clot formation initiated by the ORC.
    • Biocompatibility and cytotoxicity assay: We utilize these tests to ensure that ORC has no toxic effects on human cells. The MTT assay or similar cytotoxicity assays can be performed on a variety of cell types in contact with ORC.
    • Biodegradation study: These studies validate ORC's ability to degrade naturally within the body over time. They typically involve tracking the mass/volume loss over time or monitoring the presence of ORC metabolites in vitro.

Publication Data

Technology: Characterization of wound healing effects of ORC

Journal: International Journal of Molecular Sciences

IF: 6.028

Published: 2021

Results: The authors performed a digital search through PubMed, Scopus, Embase, and CENTRAL databases, identifying thirteen relevant studies. The evaluated research compared ORC/collagen dressings versus control treatments for managing chronic skin wounds such as diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), pressure injuries sore ulcers (PISUs), and skin graft donor site wounds. The consolidated data indicated a strong preference for ORC/collagen over traditional and hydrocolloid foam dressings in treating DFUs, VLUs, and PISUs.

Here are some of the results shown in this article:

Fig.2 Comparison of ORC properties. (Kleine, et al., 2021)Fig.2 Comparison of ORC properties. (Kleine, et al., 2021)

Applications of ORC

  • ORC can be used as a drug carrier in drug delivery systems, which can control the release rate of drugs and achieve long-term release of drugs.
  • ORC can be used as a scaffold material for cell growth. Due to its good biocompatibility and degradability, ORC can support the growth and differentiation of cells and can be gradually naturally eliminated by the body as the cells grow and metabolize, thus avoiding permanent damage to the human body.

Frequently Asked Questions

  • What are the functional properties of ORC?

ORC has the characteristics of rapid hemostasis. Its hemostatic mechanism is to gather platelets in the wound blood on the mesh gauze to quickly form a gel-like black substance and coagulate blood clots, thereby achieving the purpose of stopping bleeding. It does not rely on the normal coagulation mechanism in the human body, but quickly promotes blood coagulation through physical effects and effectively controls bleeding from small blood vessels.

  • What is the main purpose of your ORC analysis service?

Our ORC analysis service primarily serves to determine the properties, composition, and purity level of the ORC samples. This service is often utilized by clients in the pharmaceutical, biotechnology, and healthcare industries who aim to develop effective and high-quality products.

At CD Bioglyco, the Pharmaceutical Analysis Service we provide uses advanced biotechnology and analytical methods to conduct comprehensive identification and analysis of drugs. In addition, we provide in-depth ORC analysis to obtain detailed information about its chemical and biological properties. Please feel free to contact us if you are interested in our ORC analysis service.


  1. Kleine, J.; et al. Variants of oxidized regenerated cellulose and their distinct effects on neuronal tissue. International Journal of Molecular Sciences. 2021, 22(21): 11467.
This service is for Research Use Only, not intended for any clinical use.

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