Copper Gluconate Analysis Service

Copper Gluconate Analysis Service

Precision in Copper Gluconate Analysis: Just for You

Copper gluconate is a copper salt of D-gluconic acid that is widely used as a copper supplement. It's a highly bioavailable source of copper which is essential for various physiological functions such as iron transportation, brain development, skin pigmentation, immune function, and heart rhythm regulation. It has proven utility in different industries including pharmaceuticals, health supplements, and food due to its beneficial effects. At CD BioGlyco, we offer a comprehensive copper gluconate analysis service as part of our larger pharmaceutical analysis suite (Pharmaceutical and Biological Analysis Services). This testing includes but is not limited to identification, qualitative analysis, quantitative analysis, impurity detection, and reducing substance detection.

Fig.1 Copper gluconate analysis service. (CD BioGlyco)Fig.1 Copper gluconate analysis service. (CD BioGlyco)

  • Identification
    • Chemical analysis: We perform chemical analysis to determine the presence of the product by observing the reaction product of copper gluconate and specific reagents.
    • Thin-layer chromatography (TLC): TLC is a simple, rapid separation, and analytical technique for the analysis of copper gluconate. The sample spot is coated on a thin layer plate, developed with a suitable solvent, and then developed with a reagent. We analyze the composition of the sample by observing the location and color depth of the spots.
  • Qualitative analysis
    • Elemental analysis: We perform elemental analysis to determine the composition of copper gluconate by measuring the content of each element and comparing it with other known substances.
    • Molecular structure analysis: We use modern spectroscopic techniques to analyze the molecular structure of copper gluconate. For example, nuclear magnetic resonance (NMR) and mass spectrometry (MS) provide information about the internal structure and composition of molecules.
  • Quantitative analysis
    • Chemical titration: We utilize the change in conductivity or pH of a solution at the end of a chemical reaction to determine the concentration of copper gluconate. For example, copper content is determined using iodometry or EDTA titration.
    • Spectrometry: We calculate the concentration by measuring the absorbance at a characteristic wavelength according to the Lambert-Beer law. For example, UV-visible spectroscopy and atomic absorption spectrometry are used for quantitative analysis of copper.
    • Chromatography: High-performance liquid chromatography separation technology combined with detectors is utilized for quantitative analysis.
  • Impurity detection
    • Chloride ion detection: We employ a method for the detection of chloride ions that involves a reaction between silver ions and chloride ions producing a precipitate of silver chloride. The concentration of chloride ions gets established from the precipitate's weight or the alteration in solution conductivity.
    • Sulfate detection: The process of recognizing sulfates is executed through the barium sulfate precipitation method. We determine the proportion of sulfate ions by analyzing the formation and weight of the barium sulfate precipitate.
    • Arsenic detection: To recognize arsenic, we use methods such as atomic absorption spectrometry or atomic fluorescence spectrometry. Both these approaches can identify the occurrence of arsenic with pronounced sensitivity.
    • Lead detection: Graphite furnace atomic absorption spectrophotometry or atomic fluorescence spectrometry are typically used for the detection of lead. These techniques deliver a precise estimation of lead concentration.
  • Reducing substance detection
    • Chemical titration: We titrate a sample with a reducing agent (such as sodium sulfite) and determine the presence and concentration of the reducing substance by observing changes in color or conductivity.
    • Conductivity method: We use the characteristics of reducing substances to change the conductivity of the solution for detection.
    • Spectrophotometry: Spectroscopy-based methods are used to determine reducing substances by observing changes in absorbance at characteristic wavelengths.

Publication Data

Technology: Copper gluconate in vitro activity assay

Journal: Journal of Trace Elements in Medicine and Biology

IF: 3.849

Published: 2021

Results: The authors evaluated copper gluconate's in vitro effectiveness against SARS-CoV-2 on cultured Vero E6 cells. Following infection with a GFP-emitting SARS-CoV-2, cells were incubated with varying copper gluconate concentrations and assessed after 48 hours. Infection and cell viability were measured using high-content screening and XTT and propidium iodide assays, respectively. The data revealed a significant reduction in infected cells for copper gluconate levels of 25, 50, and 100 μM, with the latter also decreasing post-infection rates by 73%.

Here are some of the results shown in this article:

Fig.2 Viability of Vero E6 incubated with copper gluconate. (Rodriguez, et al., 2021)Fig.2 Viability of Vero E6 incubated with copper gluconate. (Rodriguez, et al., 2021)

Applications of Copper Gluconate

  • Copper gluconate is utilized in creams and lotions for skin care and wound healing. Copper is known for its antimicrobial properties and stimulates the production of collagen and elastin, proteins significant for skin healing and health.
  • In veterinary medicine, copper gluconate is often used as a nutritional supplement in the rearing of animals, especially pets, livestock, and poultry.
  • In horticulture and agriculture, copper gluconate is used as a micronutrient to enrich soil and improve crop quality. The copper in this compound aids in chlorophyll production and the overall nutritional value of fruits and veggies.

At CD Bioglyco, we specialize in providing Pharmaceutical Analysis Services and are committed to ensuring accurate drug research and development. Our quality analysis and control expertise includes identification, qualitative analysis, quantitative analysis, impurity detection, and reducing substance detection of copper gluconate. We extend a warm invitation for you to contact us for any queries or service requests concerning copper gluconate analysis.


  1. Rodriguez, K.; et al. Evaluation of in vitro activity of copper gluconate against SARS-CoV-2 using confocal microscopy-based high content screening. Journal of Trace Elements in Medicine and Biology. 2021, 68: 126818.
This service is for Research Use Only, not intended for any clinical use.

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