CD BioGlyco has developed chemical synthesis methods and enzyme synthesis methods to provide our customers with high-quality customized sialyl Lewis x antigen and its derivatives production services. We are confident to be your scientific assistant in the field of glycobiology.
Typical tumor-associated carbohydrate antigens are two carbohydrate structures named sialyl Lewis a and sialyl Lewis x. Sialyl Lewis x, a member of body carbohydrate, is an inherent blood-type tetrasaccharide on the surface of different cells, the lymphocyte, neutrophil, some T cells, multiple tumor cells and so on. Sialyl Lewis x is the most important ligand of the three selectins, L-selectin, E-selectin, and P-selectin, and plays important role in multiple physiological phenomena by interacting with selectins. For example, the expression of sialyl Lewis x on leukocytes contributes to their function in the inflammatory response via interaction with E-selectin expressed on endothelial cells. Sialyl Lewis x is involved in the recruitment of leukocytes to lymphoid tissues and inflammation sites.
The biosynthesis of sialylated Lewis antigens (sialyl Lewis a and sialyl Lewis x) requires first the α2,3-sialylation of Gal prior toα-1,3/4-fucosylation. ST3Gal IV and ST3Gal VI mainly act on type 2 disaccharides, leading to the biosynthesis of sialyl Lewis x. For the subsequent fucosylation, FucT VII shows a restricted substrate-specific city since it forms only sialyl Lewis x.
Fig.1 Structure of sialyl Lewis x antigen. (Wikipedia)
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