Alginate Oligosaccharide-based Biodegradable Material Development

Alginate Oligosaccharide-based Biodegradable Material Development

Quality Alginate-based Material Development Services Are Our Commitment

CD BioGlyco offers a range of services for the Development of Biodegradable Materials Based on Carbohydrates, including Monosaccharides, Disaccharides, Oligosaccharides, and Polysaccharides. Alginate oligosaccharide is an oligosaccharide obtained through the decomposition of alginate with better solubility and bioavailability. It has received particular attention due to its better pharmacological activity and beneficial role in biomedicine. We provide a one-stop alginate oligosaccharide-based biodegradable material development service from design, and preparation to analysis to support our clients' biomedical research.

Hydrogels based on alginate oligosaccharides have proven potential as delivery systems for drugs, proteins, and lysosomes. In addition to this, alginate oligosaccharide is also used as a stabilizer in nanoemulsion preparation to encapsulate some unstable nutrients and improve their bioavailability and stability. Based on our decades of accumulated expertise and advanced equipment, we develop hydrogels and nanoparticles for drug delivery, encapsulation, etc. The preparation process is as follows:

  • Preparation of alginate oligosaccharide-based biodegradable materials

We mainly prepare biodegradable materials such as hydrogels by solvent-casting, freeze-thaw, etc. Membrane thickness, mechanical properties, adhesion properties, and the proportion of alginate oligosaccharides affect the physical, chemical, and biological properties of biodegradable materials. During the preparation process, we design multiple parameter levels to ensure that we get the best performance of alginate oligosaccharide-based biodegradable materials. In addition, we also chemically modify the alginate oligosaccharide to improve its physicochemical and biological properties.

  • Analysis of alginate oligosaccharide-based biodegradable materials
    • Physicochemical properties characterization: Nuclear magnetic resonance (NMR) analysis, X-ray diffraction (XRD) analysis, tensile testing, compression testing, scanning electron microscopy (SEM) analysis, etc.
    • Biological characterization: antibacterial activity testing, biocompatibility testing
    • Biodegradability determination

Flowchart of alginate oligosaccharide-based biodegradable material development.Fig.1 Flowchart of alginate oligosaccharide-based biodegradable material development. (CD BioGlyco)

Publication Data

Technology: Freeze-thaw

Journal: Marine Drugs

IF: 4.073

Published: 2019

Results: In the present study, alginate oligosaccharide gels were prepared by freeze-thaw technique. The method involves the crystallization of solvent during freezing, which increases the forces between the alginate oligosaccharide chains and space compression. Eventually upon thawing the chains are joined and form a hydrogel. Conventional antifungal drugs were embedded in hydrogels and testing their drug release times. The results showed that alginate oligosaccharide prolonged drug retention time and may enhance antifungal drug resistance. This study provides an effective strategy for the development of biodegradable materials based on alginate oligosaccharides.

Preparation and characterization of alginate oligosaccharide-based hydrogels.Fig.2 Preparation and characterization of alginate oligosaccharide-based hydrogels. (Szekalska, et al., 2019)

Frequently Asked Questions

  • Why is alginate oligosaccharide popular in the development of biodegradable materials?

Alginate oligosaccharide is an oligomer produced by the degradation of alginate and consists of only two monosaccharides that are isomers of each other. It not only retains the physicochemical properties of alginate but also derives several other excellent biological properties that give it great potential for industrial and biomedical applications. Also, the abundant seaweed resources make alginate oligosaccharides more economical to develop and apply than other oligosaccharides.

  • What are the factors affecting the drug transportation efficiency of alginate oligosaccharide-based biodegradable materials?

The alginate oligosaccharide-based films are used to deliver specific drugs to the target organ or target site for therapeutic effect. Among these factors, film thickness, pH of the film surface, swelling characteristics, and mucosal adhesion strength are important factors affecting the delivery efficiency.

Highlights of Us

  • We are a leader in the development and preparation of alginate oligosaccharide-based biodegradable materials.
  • We prepare high-performance biodegradable materials by adjusting the size, ratio, and concentration of alginate oligosaccharides, adopting appropriate preparation processes, etc.
  • We have perfected the series of design, development, preparation, and analysis of biodegradable materials.

CD BioGlyco provides new material solutions for biomedical research based on the development, preparation, and sales of high-performance biodegradable materials. Please feel free to contact us for more information about the development of alginate oligosaccharide-based biodegradable materials. Our team of scientists will surely give you the most satisfactory solutions and products.


  1. Szekalska, M.; et al. Alginate oligosaccharides affect mechanical properties and antifungal activity of alginate buccal films with posaconazole. Marine Drugs. 2019, 17(12): 692.
This service is for Research Use Only, not intended for any clinical use.

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