Muscle cell glycosylation is the combination of glucose with muscle protein to form a glycosylation product. High blood glucose stimulates an increase in the concentration of glucose in the body, and the excess glucose combines with amino acids in muscle protein to form a glycosylation product. The glycosylation product affects the structure and function of muscle protein, disrupting the normal metabolic processes within muscle cells. Muscle cell glycosylation is one of the common complications in diabetic patients. Long-term persistent hyperglycemia and accumulation of glycosylation products lead to pathological changes such as muscle tissue fibrosis, sclerosis, and degeneration of myogenic fibers, which eventually lead to reduced exercise capacity, pain, and other symptoms. Therefore, research on how to mitigate the negative effects of muscle cell glycosylation on the body is important to prevent and treat the complications of diabetes mellitus.
Fig.1 Flow chart of high-throughput screening (HTS) of compounds that alter glycosylation in muscle cells based on plant lectins. (CD BioGlyco, 2023)
HTS techniques allow rapid access to multiple compounds with the ability to alter muscle cell glycosylation, which provides the basis for the development of novel drugs for diabetes. CD BioGlyco is focused on providing professional glycan analysis services and accelerating research related to glycobiology. We offer a variety of HTS technologies for glycoconjugate screening, including HTS of compounds that alter glycosylation in muscle cells. The services we provide are not limited to the following:
CD BioGlyco provides efficient and accurate HTS services for compounds that alter muscle cell glycosylation to help you accelerate your research and reduce research costs. Our dedicated team also provides complete solutions and the best after-sales service to ensure your research process. If you are interested in our services, please contact us for more details.