Structural Analysis of Glycosaminoglycans

At present, the structure and biological functions of glycosaminoglycans are being extensively studied, and understanding the structure of glycosaminoglycans can help us deeply study its functions and tap its potential. CD BioGlyco has a variety of advanced technology platforms and analysis tools that can help customers study glycosaminoglycans systematically. We have confidence to be your essential research assistant in the field of glycobiology.

Background

Glycosaminoglycan (GAG) is a linear polysaccharide with free or protein-bound ubiquitous in the extracellular matrix of most animal tissues and cell surfaces. GAG is a polymer composed of repeating O-linked disaccharide units formed by amino sugars and uronic acid, except that keratan sulfate (KS) has β-D-galactose (Gal) instead of uronic acid. Their biosynthesis is under complex control and confers a domain structure essential to their ability to bind to protein partners.

Fig 1. Structures of the glycosaminoglycan classesFig 1. Structures of the glycosaminoglycan classes (Gregory, O.S.; Joseph, Z. 2011)

In the past, GAG was considered a filler material, but it was later discovered that it is involved material, but now it has been discovered that it is involved in many basic functions of cell communication, differentiation and growth. Therefore, these molecules can be designed into potential therapeutic agents, among which heparin has been the anticoagulant of choice for decades. GAG can also affect coagulation, inflammation, cancer, virus infection and tissue development. Its great potential in tissue regeneration and the development of antiviral and antitumor drugs are uncovered.

The key to understanding the function of GAG is the need for a sufficiently fast and sensitive method to analyze its molecular structure, protein binding and other biological activity related sulfation, acetylation and uronic acid epimerization, etc.

Fig 2. Different applications of glycosaminoglycansFig 2. Different applications of glycosaminoglycans (Köwitsc, A.; et al. 2017)

Services

The systematic GAG structural analysis services in CD BioGlyco include but are not limited to the following aspects.

  • Disaccharide Analysis
  • Oligosaccharide Analysis
  • Linkage analysis of neutral, uronic acids or amino-residues
  • Linkage analysis of Kdo(2-keto-3-deoxy-octulosonic acid)
  • GAG-protein complexes analysis

Applications

  • GAG function and structure analysis
  • Tissue engineering and regenerative medicine research
  • Application in cosmetics and health products
  • Development glycosaminoglycan-based therapeutic

Advantages of Us

  • Combination of multiple advanced technology platforms
  • One-stop service from separation and purification to structural analysis
  • Experienced researchers and trusted results
  • 24 hours after-sales service

CD BioGlyco has a lot of successful experience in the separation and profiling of glycosaminoglycans, and our services have helped customers from all over the world, the efficient services and accurate results have gained a good reputation for our company.

Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.

References:

  1. Gregory, O.S.; Joseph, Z. Analysis of glycosaminoglycans using mass spectrometry. Current Proteomics. 2011, 8: 325-336.
  2. Köwitsc, A.; et al. Medical application of glycosaminoglycans: a review. Journal of Tissue Engineering and Regenerative Medicine. 2017, 12(1): 23-41.
This service is for Research Use Only, not intended for any clinical use.

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