Immunoglobulin G (IgG) is an essential antibody. CD BioGlyco has developed a variety of reliable strategies to provide clients with detection of blood IgG levels to reveal hyper-responsiveness to antigenic stimuli or physiological abnormalities at the site of IgG production, among other disorders.
IgG is a class of protein molecules that function as antibodies to help fight pathogens and protect the body from infections. The detection and quantification of human IgG levels are clinically important for allergy testing, assessing immune responses, and measuring the body's response to antigenic stimuli. And it can provide information about any physiological abnormalities at the site of IgG production and other neurological complications related to diseases such as CHIKV and multiple sclerosis. In addition, the detection of IgG also has an impact on the field of monoclonal antibodies (mAbs) for the treatment of cancer, autoimmune diseases and Alzheimer's disease.
The development of real-time, reliable and cost-effective technologies is significant to monitor treatment efficacy and improve patient care through personalized treatment protocols. Currently, IgG is quantified by techniques such as ELISA, fluorescence microscopy, immunoassays, mass spectrometry, liquid chromatography or cell-based assays. Routine analysis-based methods such as ELISA and cell-based immunofluorescence (IF) involve the use of a specific antigen to bind the IgG antibody followed by the detection of Ig biomarkers or Ig antigen complexes.
Fig.1 Overview of surfactant hydrodynamic retardation effect detector (SHRED). (A) IgG molecular structure. (B) Theory of operation. (C) Implementation of a protein detector. (Fatima, 2019)
CD BioGlyco has developed various methods for providing the service of glyco-biomarker IgG detection for our clients. The strategies we provide include but are not limited to:
With a world-class research platform and highly trained staff, CD BioGlyco has designed and validated multiple strategies for the rapid and sensitive detection of IgG. If you have a demand for glyco-biomarker detection services, please feel free to contact us.