Lymphoma is the sixth most common cancer. Increased metabolic activity of lymphoma tumor cells associated with high expression of glycolysis-related proteins, has already been described and indicates a pivotal role for glucose and glycogen metabolism in the malignant progression of the disease. Studies have shown that glycosylation is a key regulator for the distant metastasis of mouse lymphoma cells in animal models through using mouse lymphoma cell lines. In addition, the concentration of sialic acid has been reported to be elevated in the serum of patients with malignant lymphoma, suggesting that sialic acid may be associated with tumor cell aggressiveness in lymphoma.
Fig.1 Increased expression and activation of the molecules that promote tumor cell survival and modulate glucose/glycogen metabolism. (Jalali & Ansell, 2020)
To support Cancer Glycogene research, CD BioGlyco offers glycogene discovery services in lymphoma and other cancers. The services we provide include but are not limited to:
Fig.2 Example of the discovery process in lymphoma. (CD BioGlyco)
Over the years, with constant collaboration and innovation, CD BioGlyco has enriched the Glycogenomics Platform to cover our client's essential needs. We continue to conduct research and expand our service area to help our clients achieve their goals. In addition, our expert team has extensive experience in Glycogene Editing and Glycogene Delivery. Welcome to contact us for custom service. We look forward to your happy cooperation.