Numerous clinical and epidemiological studies have demonstrated a strong relationship between inflammation and cancer. Inflammatory signaling pathways are widely involved in the regulation of glucose metabolism in tumor cells. The inflammatory microenvironment is one of the important incentives for tumor lesions. Chronic inflammation can affect the reprogramming of glucose metabolism in tumor cells and promote tumorigenesis. In recent years, research on the relationship between chronic inflammation and tumors has made progress, but there are still many problems to be solved. Therefore, CD BioGlyco uses the MOPCGM platform to identify unknown glucose metabolism-related genes and proteins with important functions in the chronic inflammation-cancer transformation process through high-throughput screening technology, thereby revealing the molecular mechanism of inflammation-mediated glucose metabolism reprogramming.
Fig. 1 Glucose metabolic reprogramming in anti- and pro-inflammatory immune response (Sun L, et al., 2020)
Inflammatory cells can analyze inflammatory factors involved in the reprogramming of tumor cell glucose metabolism and promote aerobic glycolysis, thereby mediating tumor cell growth and invasion. We can use the MOPCGM platform to analyze the regulatory effect of inflammatory factors on the reprogramming of glucose metabolism in tumor cells using multi-omics technology and conduct further functional studies through molecular biology. The interleukins and tumor necrosis factors that we can provide the above analysis services are as follows.
The specific analysis services we can provide are as follows, including but not limited to:
Immune cell glucose metabolism is closely related to tumor-related inflammation. For example, macrophages can remodel glucose metabolism according to changes in the tumor microenvironment, produce pro-inflammatory factors, and promote tumor progression. Therefore, we were able to analyze the relationship between the reprogramming of immune cell glucose metabolism and tumor-associated inflammation and explore the molecular mechanism of inflammation-cancer development.
CD BioGlyco provides analysis services for the interaction between glucose metabolism reprogramming and tumor-associated inflammation. Our experienced teams of scientists, researchers, and technicians provide a fast turnaround, and high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.