Interplay Between Glucose Metabolism Reprogramming and Tumor-associated Inflammation

Numerous clinical and epidemiological studies have demonstrated a strong relationship between inflammation and cancer. Inflammatory signaling pathways are widely involved in the regulation of glucose metabolism in tumor cells. The inflammatory microenvironment is one of the important incentives for tumor lesions. Chronic inflammation can affect the reprogramming of glucose metabolism in tumor cells and promote tumorigenesis. In recent years, research on the relationship between chronic inflammation and tumors has made progress, but there are still many problems to be solved. Therefore, CD BioGlyco uses the MOPCGM platform to identify unknown glucose metabolism-related genes and proteins with important functions in the chronic inflammation-cancer transformation process through high-throughput screening technology, thereby revealing the molecular mechanism of inflammation-mediated glucose metabolism reprogramming.

Glucose metabolic reprogramming in anti- and pro-inflammatory immune responseFig. 1 Glucose metabolic reprogramming in anti- and pro-inflammatory immune response (Sun L, et al., 2020)

What We Do

  • Analysis of the effects of inflammatory mediators on the reprogramming of glucose metabolism

Inflammatory cells can analyze inflammatory factors involved in the reprogramming of tumor cell glucose metabolism and promote aerobic glycolysis, thereby mediating tumor cell growth and invasion. We can use the MOPCGM platform to analyze the regulatory effect of inflammatory factors on the reprogramming of glucose metabolism in tumor cells using multi-omics technology and conduct further functional studies through molecular biology. The interleukins and tumor necrosis factors that we can provide the above analysis services are as follows.

The specific analysis services we can provide are as follows, including but not limited to:

  • Analysis of the pathway by which inflammatory factors affect glucose uptake by tumor cells
  • Analysis of the effects of inflammatory factors on glucose transporters
  • Analysis of the relationship between inflammasome activation and the reprogramming of glucose metabolism in cancer cells
  • Analysis of the effect of glucose metabolism reprogramming in tumor-associated immune cells on inflammation

Immune cell glucose metabolism is closely related to tumor-related inflammation. For example, macrophages can remodel glucose metabolism according to changes in the tumor microenvironment, produce pro-inflammatory factors, and promote tumor progression. Therefore, we were able to analyze the relationship between the reprogramming of immune cell glucose metabolism and tumor-associated inflammation and explore the molecular mechanism of inflammation-cancer development.

  • Analysis of the effects of glycolysis-related enzymes on tumor cell inflammation
  • Analysis of the effects of pentose phosphate pathway-related enzymes on tumor cell inflammation

Our Advantages

  • We are able to provide proteomic analysis services of inflammasomes of different cells.
  • We are able to analyze the relationship between inflammation and the reprogramming of immune glucose metabolism in tumor-associated fibroblasts, tumor-associated macrophages, etc.

Applications

  • To explore novel anti-inflammatory mechanisms mediated by glucose metabolism reprogramming in cancer cells.
  • Exploration of new mechanisms of inflammasome activation.
  • Exploring new mechanisms of immunotherapy resistance.

CD BioGlyco provides analysis services for the interaction between glucose metabolism reprogramming and tumor-associated inflammation. Our experienced teams of scientists, researchers, and technicians provide a fast turnaround, and high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.

Reference:

  1. Sun L, et al. Metabolic Reprogramming in Immune Response and Tissue Inflammation. Arterioscler Thromb Vasc Biol. 2020 Sep; 40(9): 1990-2001.
This service is for Research Use Only, not intended for any clinical use.

About Us

CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.

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