Glucuronic acid is derived from glucose. It rarely exists in free form in nature, mostly in glycosides or polysaccharides. In the cell walls of plants, it is one of the components of the xylan skeleton. Glucuronic acid is an important intermediate in carbohydrate metabolism. In animals, it is combined with phenols, sterols, and aromatic carboxylic acids, and excreted as glucuronates.
After the activation of glucuronic acid into uridine diphosphate (UDP)-glucuronic acid, it can be incorporated into chondroitin sulfate. In the presence of nicotinamide adenine dinucleotide phosphate (NADP), glucuronic acid is also reduced to L-gulonic acid, which is a precursor to ascorbic acid. In vivo, phenol, bilirubin, or drugs can combine with glucuronic acid to form various glucuronides. In addition, some hormones such as thyroid hormones and certain steroid hormone derivatives can be detoxified by glucuronic acid.
Fig.1 Schematic diagram of synthesis of UDP-glucuronic acid. (Chung & Bhagavan, 2023)
Glucuronic acid plays an important role in the metabolic network of organisms. With the rich experience accumulated in the field of glycobiology, CD BioGlyco has a huge advantage in glucuronic acid metabolism analysis. We analyze glucuronic acid monomers in a variety of mixed samples.
Fig.2 Different approaches of glucuronic acid metabolism analysis. (CD BioGlyco)
With a customer-centric philosophy, CD BioGlyco provides accurate and affordable glucuronic acid metabolism analysis services to clients around the world. If you are interested in other Monosaccharide, Disaccharide, Oligosaccharide, and Polysaccharide Metabolism Analysis services we provide, please browse our Carbohydrate Metabolism Analysis. Please feel free to contact us for more information.