CD BioGlyco is a world-leading independent biotechnology company, focusing on high-quality innovative services related to glycobiology. CD BioGlyco has professional glycomedicine development teams with multiple world-leading technologies to help customers comprehensively promote the development of carbohydrate-based cardiovascular glycomedicine.
Cardiovascular diseases (CVD) represent one of the most frequent causes of death globally. Under pathologic conditions, thrombosis or thromboembolism blocks the natural blood flow, leading to related organ dysfunction, including ischemic stroke, peripheral artery disease, and ischemic heart disease consisting of chronic coronary artery disease and acute coronary syndrome. Therefore, antithrombotic therapy, including anticoagulant therapy, antiplatelet therapy, and thrombolytic therapy, is widely applied in these scenarios and regarded as the cornerstone of CVD therapy.
Carbohydrate-based drugs occupy an unshakable position in the field of antithrombotic therapy. The earliest natural anticoagulant heparin was discovered in dog liver in 1916, and belongs to the glycosaminoglycan polysaccharide family. Importantly, a rare pentasaccharide unit of heparin binds strongly to antithrombin III to mediate the robust anticoagulant effects. In addition, the purinergic receptor P2Y12, which is stimulated by ADP but inhibited by ATP, plays an important role in platelet hemostasis. Therefore, some adenine nucleotide analogs own antiplatelet effects.
Fig.1 Schematic representation of novel antithrombotic approaches. (Mcfadyen & Peter,2017)
CD BioGlyco has developed a powerful carbohydrate-based glycomedicine development platform and various systematic solutions for the development of carbohydrate-based cardiovascular glycomedicine. CD BioGlyco provides carbohydrate-based antiplatelet glycomedicine development service and the antiplatelet activity can be determined.
With a first-class experimental platform and professional research teams, CD BioGlyco is committed to ensuring customer the highest level of satisfaction. Our professional research teams provide customers with high-quality carbohydrate-based cardiovascular glycomedicine development services according to their needs. If you are interested in our services, please contact us to obtain more information.