Microarray technology is a high-throughput (HT) experimental technique for the simultaneous detection and analysis of multiple biomolecules in a large number of samples. It works by immobilizing thousands of different probe molecules on a solid surface, to create a small array. These probes can be DNA, RNA, proteins, antibodies, glycan, and more. Each probe location has a unique identifier, enabling accurate identification and analysis of which molecules bind specifically to the corresponding probe. Glycan microarrays involve immobilizing numerous different sugar molecules onto a microarray which are bound to specific probes to detect reactions. This technique is capable of simultaneously detecting the conjugation of multiple sugars to the probe, thus providing the ability to HT screen and characterize specific sugar-binding partners. A wide range of natural glycan structures can be covered in Glycan Microarrays, allowing a comprehensive understanding of the interactions between glycans and other biomolecules.
Fig.1 Microarray-based technologies for studies of biological processes. (Shin, et al., 2005)
CD BioGlyco has established an advanced Glycobiology Microarray Platform, which provides specialized HT Glycan Screening Services based on glycan microarray assay. We simultaneously test the interaction of a large number of glycans of different structures with target molecules, opening up entirely new possibilities for your glycobiology research. Our HT glycan screening services are listed below:
Fig.2 Process of glycan-protein binding analysis based on glycan microarrays. (CD BioGlyco, 2023)
CD BioGlyco provides glycan microarrays-based HT glycan screening service to help clients accurately assess the binding affinity and specificity of candidate glycans to target proteins. Please feel free to contact us if you are interested in our service, and we will be delighted to provide you with support and assistance.