Siglecs can be classified into many groups using various categorization criteria. For example, Siglecs can be divided into two groups CD33-Related Siglecs and conserved Siglecs, depending on how much of their sequence is conserved. The word "conserved" actually refers to the fact that conserved Siglecs have been maintained throughout evolution and are constant in rodents and humans. CD BioGlyco has established a Microarray Platform and offers Sialic Acid Microarray and Lectin Microarray Assay for customers to study conversed Siglecs.
Fig.1 Presence of Siglec family members in selected mammalian species. (Bornhöfft, et al., 2018)
There are four members of the Conserved family, Siglec-1 (Sialoadhesin/ CD169), Siglec-2 (CD22), Siglec-4 (myelin-associated glycoprotein/MAG), and Siglec-15, The sequence identity between them is low. but they have clear orthologues in all mammalian species examined. Due to these Siglecs all binding to sialic acid, CD BioGlyco provides Sialic Acid Analysis Service for customers to study the ability of Siglecs to bind to sialic acid.
CD BioGlyco provides excellent microarray analysis services and can customize microarrays to meet various research needs. We want to be your assistant in the field of Siglecs research, so please contact us if you are interested in our services.
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