The Role of Nucleosides

Nucleic acid is an essential biomolecule in the process of life activities, and its basic structural unit is a nucleotide, which is composed of a pentose sugar, base, and phosphate. Which consists of base and pentose sugar and is also known as nucleoside. Nucleoside is a general term for a class of glycosides. Clinical studies have shown that nucleosides and drugs made from them are an important class of drugs for the treatment of viral infections, tumors, and AIDS. Of the antiviral drugs currently in use, 50% are nucleosides. Anti-tumor drugs such as cytarabine and trifluridine also belong to the nucleoside class. In recent years, nucleosides have become the focus of research by pharmaceutical workers.

In the synthesis of nucleosides, there are two main methods: Chemical Synthesis and biological (enzymatic) synthesis. These two synthesis methods have their advantages and have been widely considered and studied by researchers.

Fig.1 Diagram of the catalytic mechanism of nucleoside phosphorylases. (Fan, et al., 2005)

Nucleoside Enzymatic Synthesis Service at CD BioGlyco

To produce nucleosides more efficiently, CD BioGlyco has comprehensively researched biological methods to produce nucleosides. At the heart of this method is the catalytic action of enzymes. We offer two enzymes, ribose phosphorylase, and deoxyribosyltransferase, to catalyze the synthesis of nucleosides.

• Ribose phosphorylase catalyzes the conversion of different purine and pyrimidine bases and is strictly base-specific, reducing side reactions and thus catalyzing the production of nucleosides more efficiently.
• Deoxyribosyltransferase catalyzes the conversion between purine bases and purine nucleosides and between pyrimidine bases and pyrimidine nucleosides. No intermediates are produced during the catalytic process.

CD BioGlyco offers a method for the enzymatic production of nucleosides that is characterized by high efficiency, mild reaction conditions, simple operation, high reaction specificity, few side reactions, and simple isolation and purification of reaction products. In the process of nucleoside production, we will continue to optimize the production solution to provide customers with the best production service.

Fig.2 Uses of the two enzymes. (CD BioGlyco)

Applications

• Nucleosides could be used as feedstock for the production of antiviral and antitumor drugs.
• Nucleosides are used in the development of anticancer chemotherapeutic agents.

Advantages

• We have a non-toxic and specialized method of enzymatic production of nucleosides that helps in drug discovery and development.
• Our nucleoside production services help researchers to explore the physiological functions of nucleosides. For example, in anti-tumor and anti-virus.

CD BioGlyco has many years of experience in nucleoside production. We provide our clients with multiple routes to produce nucleosides and provide them with better service by continuously optimizing experimental solutions. If you are interested in our services, please feel free to contact us.