Properties
Description
PEI-grafted chondroitin sulfate (PEI-CS) electrostatically complexes cationic polyethyleneimine with anionic chondroitin, creating nucleic acid delivery vehicles with reduced cytotoxicity.
Glycan Name
Chondroitin sulfate
Glycan Structure
The glycan structure of chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) composed of repeating disaccharide units. Each unit consists of:
N-acetyl-D-galactosamine (GalNAc) (β1→4 linked)
D-glucuronic acid (GlcA) (β1→115 linked)
Source
Chemical synthesis
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Chondroitin sulfate-polyethyleneimine can be used for its potential to engineer charge-tunable polyplexes for gene delivery optimization.
