Cyclodextrin Analysis Services
Comprehensive analytical characterization of cyclodextrin complexes is essential to provide adequate support for selecting the most appropriate cyclodextrin for each guest molecule. CD BioGlyco has the confidence to provide our clients with one-stop cyclodextrin analysis services.
Cyclodextrins are cyclic oligosaccharides whose physicochemical properties can be significantly modified by forming clathrates with plenty of hydrophobic guest molecules. Both analytical chemists and pharmaceutical scientists have long been exploiting these properties for solubility enhancement of insoluble drugs, stability enhancement, protection against oxidation, light-induced reaction and loss by evaporation, etc. Cyclodextrins have no chromophores or fluorophores, so they cannot be detected using traditional HPLC detectors, such as fluorescence detectors. It's also challenging to detect cyclodextrins by high-performance liquid chromatography (HPLC). However, other HPLC detections such as mass spectrometric detector, evaporative light scattering detector (ELSD), refractive index (RI) detector, and charged aerosol detector (CAD) can also be applied. Today, cyclodextrins are considered to be versatile additives of many kinds of molecular recognition-based analytical methods, such as separation science, spectroscopic methods, electroanalyses, and single-molecule sensing. The development of novel and improved analytical technologies is highly valuable in the pharmaceutical field in order to better predict and understand the aggregation phenomenon as well as their detection and quantification.
A fast and reliable tool to follow reactions or identify cyclodextrins. Identification and purity analysis of parent and derivatized cyclodextrins.
Quantitative determination of parent and derivatized cyclodextrins. Separation of the open-ringed decomposition products, the linear maltooligomers.
The suitable tools to evaluate substitution patterns as well as to study clathrate formation.
A routine quality control technique in the pharmaceutical industry for identification purposes.
The determination of molecular weight and purity of Cyclodextrins.
Characterization of cyclodextrin derivatives by chemical degradation.
Solid-phase characterization of different cyclodextrins.
The purity analysis of any charged derivatized cyclodextrins including positively charged ones.
Characterizing the aggregation behavior of cyclodextrin molecules in aqueous solutions.
CD BioGlyco delivers comprehensive cyclodextrin analysis services designed to address diverse industry needs. Our capabilities include confirmation of inclusion complex formation in solution and solid states, precise stoichiometry determination (host: guest ratio), and purity/quantification analysis across matrices and formulations. We further evaluate physicochemical property modifications (solubility, dissolution rate, stability) induced by complexation and leverage cyclodextrins for chiral separation of enantiomeric mixtures. To optimize outcomes, we provide formulation support for cyclodextrin derivative selection and preparation methods, alongside stability studies of complexes under varied conditions. Additionally, we characterize complexes for bioavailability enhancement and assess their efficacy in masking taste/odor in end products.
DOI.: 10.3390/polysaccharides3010001
Journal: Polysaccharides
IF: 5.5
Published: 2021
Results: This review details the unique truncated cone structure of native cyclodextrins (α-, β-, and γ-cyclodextrin), characterized by a hydrophobic internal cavity and hydrophilic exterior, which underpins their ability to form inclusion complexes with various molecules. It explores key physicochemical properties like conformational flexibility, aqueous solubility variations, and aggregation behavior, emphasizing how chemical modifications (e.g., hydroxypropyl derivatives) enhance functionality. The article examines factors influencing complexation (cavity size, guest properties, water displacement) and discusses the broad applications of cyclodextrins, including pharmaceutical drug delivery (solubility enhancement, stability, bioavailability), environmental remediation (pollutant removal), food technology (flavor encapsulation, cholesterol reduction), textiles, cosmetics, and emerging uses in solar energy materials and sensors. The authors conclude that cyclodextrins' versatility and biocompatibility ensure continued scientific and industrial interest.
Building on the specialized analytical expertise developed for cyclodextrin analysis services-crucial for characterizing critical quality attributes like complexation efficiency, purity, and physicochemical properties of these versatile pharmaceutical excipients comprehensive Pharmaceutical Excipient Analysis suite extends to essential natural polymers like starches. This includes rigorous Wheat Starch Analysis, Potato Starch Analysis, and Tapioca Starch Analysis. These services focus on evaluating key parameters such as granule morphology, amylose/amylopectin ratio, moisture content, microbial load, swelling power, gelatinization behavior, and purity (including absence of contaminants like residual proteins or sulfites). By providing detailed characterization of these fundamental excipients, alongside cyclodextrins, we ensure their functionality, consistency, and safety within pharmaceutical formulations.
CD BioGlyco employs various approaches to provide you with professional and rapid cyclodextrin analysis services. If you want to know more about the service, please feel free to contact us.
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