Cyclodextrin Analysis Services

Comprehensive analytical characterization of cyclodextrin complexes is essential to provide adequate support for selecting the most appropriate cyclodextrin for each guest molecule. CD BioGlyco has the confidence to provide our clients with one-stop cyclodextrin analysis services.

Analytical Characterization of Cyclodextrins

Cyclodextrins are cyclic oligosaccharides whose physicochemical properties can be significantly modified by forming clathrates with plenty of hydrophobic guest molecules. Both analytical chemists and pharmaceutical scientists have long been exploiting these properties for solubility enhancement of insoluble drugs, stability enhancement, protection against oxidation, light-induced reaction and loss by evaporation, etc. Cyclodextrins have no chromophores or fluorophores, so they cannot be detected using traditional HPLC detectors, such as fluorescence detectors. It's also challenging to detect cyclodextrins by high-performance liquid chromatography (HPLC). However, other HPLC detections such as mass spectrometric detector, evaporative light scattering detector (ELSD), refractive index (RI) detector, and charged aerosol detector (CAD) can also be applied. Today, cyclodextrins are considered to be versatile additives of many kinds of molecular recognition-based analytical methods, such as separation science, spectroscopic methods, electroanalyses, and single-molecule sensing. The development of novel and improved analytical technologies is highly valuable in the pharmaceutical field in order to better predict and understand the aggregation phenomenon as well as their detection and quantification.

Our Major Analytical Techniques

  • TLC

A fast and reliable tool to follow reactions or identify cyclodextrins. Identification and purity analysis of parent and derivatized cyclodextrins.

  • HPLC

Quantitative determination of parent and derivatized cyclodextrins. Separation of the open-ringed decomposition products, the linear maltooligomers.

  • NMR

The suitable tools to evaluate substitution patterns as well as to study clathrate formation.

  • IR

A routine quality control technique in the pharmaceutical industry for identification purposes.

  • MS

The determination of molecular weight and purity of Cyclodextrins.

  • Gas chromatographic methods

Characterization of cyclodextrin derivatives by chemical degradation.

  • Either single crystal or powder X-ray diffraction

Solid-phase characterization of different cyclodextrins.

  • Capillary electrophoresis methods

The purity analysis of any charged derivatized cyclodextrins including positively charged ones.

  • Dynamic light scattering methods

Characterizing the aggregation behavior of cyclodextrin molecules in aqueous solutions.

  • Viscosity measurements
  • Osmolality measurements
  • Determination of the water content

Cyclodextrin Analysis Services

Analysis Workflow

Analysis Workflow

Advantages of Us

  • Professional analytical research team
  • Diversified analytical tools to provide precise results
  • Detailed data and analysis reports
  • High reliability and short test cycles

CD BioGlyco employs various approaches to provide you with professional and rapid cyclodextrin analysis services. If you want to know more about the service, please feel free to contact us.


  1. Szente, L.; et al. Analytical characterization of cyclodextrins: History, official methods and recommended new techniques. J Pharm Biomed Anal. 2016, 130: 347-365.
This service is for Research Use Only, not intended for any clinical use.

About Us

CD BioGlyco is a world-class biotechnology company with offices in many countries. Our products and services provide a viable option to what is otherwise available.

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