Custom Cyclodextrin Development
Overview
Cyclodextrins are still regarded as novel excipients of unexplored potential since their discovery in the late 19th century. Over the years, CD BioGlyco has established a multifunctional and advanced GlycoTM Synthesis Platform and cyclodextrin development platform to facilitate research in cyclodextrin development. We are dedicated to providing our clients with the highest quality professional services.
Key Technologies
Microwave irradiation; Supercritical carbon dioxide; Co-precipitation; Spray-dried
Properties of Cyclodextrin
Cyclodextrins are enzyme-modified starch derivatives, cyclic oligosaccharides containing six (α-cyclodextrin), seven (β-cyclodextrin), eight (γ-cyclodextrin), or more (α-1,4-)-linked D-glucopyranose units. The cyclodextrins have toroidal shapes, with the smaller and the larger pockets of the toroid exposed to the solvent secondary and primary hydroxyl groups respectively. As a consequence of this arrangement, cyclodextrins can host plenty of hydrophobic molecules, or part of them inside their cavity through non-covalent interactions to form host-guest type clathrate. Cyclodextrin clathrate containing hydrophobic molecules can penetrate body tissues, these could be used to release biologically active compounds under specific conditions. Cyclodextrins are chemically versatile and can be modified to get mono- or poly-substituted derivatives, which can improve their properties (i.e., solubility and stability), and tune their complexation abilities. The complexation process leads to significant changes in guest spectral properties, reactivity, volatility, solubility, and stability. In addition, they are widely used in food, pharmaceutical, agriculture, and chemical industries, as well as the cosmetics industry, oilfield applications, and biotechnology fields.
Our Services
Cyclodextrins have been utilized in a diversity of technological fields. For instance, the development of new and improved analytical technologies using cyclodextrins is highly valuable for the pharmaceutical field. With a professional synthesis platform, CD BioGlyco provides our clients with scientific assistance in the research of cyclodextrins. Particularly, we provide several strategies to prepare cyclodextrins-guest complexes including kneading, grinding, microwave irradiation, supercritical carbon dioxide, co-precipitation, and spray-dried. The cyclodextrins-guest complexes can be applied to the development of pharmaceutical and non-pharmaceutical cyclodextrins.
Publication Data
DOI.: 10.3390/ijms25084547
Journal: International Journal of Molecular Sciences
IF: 4.9
Published: 2024
Results: In this article, the authors provided a comprehensive overview of cyclodextrins, which are cyclic oligosaccharides composed of at least six d-(+)-glucopyranose units, with natural variations (α-, β-, and γ-cyclodextrins) differing in size and solubility. They highlighted the unique structure of cyclodextrins, featuring a hydrophilic exterior and a hydrophobic inner cavity, which enables them to encapsulate various molecules. The authors discussed the extensive and diverse applications of cyclodextrins across numerous industries, including pharmaceuticals, food, cosmetics, textiles, biotechnology, agriculture, and environmental processes, attributing their utility to properties like biocompatibility, biodegradability, and cost-effectiveness. Furthermore, the article delves into research advancements concerning the design, synthesis, characterization, and practical uses of cyclodextrins, emphasizing their capacity to enhance the solubility and bioavailability of poorly water-soluble substances and to act as catalysts in various reactions.
Workflow
Applications
- Designing cyclodextrin derivatives to improve the solubility, bioavailability, stability, and controlled release of poorly water-soluble drugs.
- Utilizing custom cyclodextrins as excipients, carriers, or even active pharmaceutical ingredients (APIs) themselves.
- Integrating custom cyclodextrins into sensor designs for the selective detection of specific biomolecules, environmental contaminants, or drugs.
Advantages
- We use advanced techniques (like nuclear magnetic resonance (NMR), high-performance liquid chromatography (HPLC), etc.) for characterizing cyclodextrin complexes to select the most suitable ones.
- Our track record and experience ensure dependable results and products.
- Our dedicated technological infrastructure facilitates comprehensive cyclodextrin research.
- Our expertise spans drug delivery systems (e.g., mucoadhesive gels, creams, films) as well as uses in food (stabilizing/thickening agents) and catalysis (enzyme mimics).
Frequently Asked Questions
Associated Services
| Alpha Cyclodextrin Analysis Service | Beta Cyclodextrin Analysis Service | Gamma Cyclodextrin Analysis Service |
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CD BioGlyco is the most reliable partner with lots of experienced scientists. We are committed to providing you with high-quality analysis services and reliable products of cyclodextrins. If you are interested in our services, please contact us for more details.
Reference
- Esteso, M.A.; Romero, C.M. Cyclodextrins: properties and applications. International Journal of Molecular Sciences. 2024, 25(8): 4547. (Open Access)
