Cyclodextrins are still regarded as novel excipients of unexplored potential since their discovery in the late 19th century. Over the years, CD BioGlyco has established a multifunctional and advanced GlycoTM Synthesis Platform and cyclodextrin development platform to facilitate research in cyclodextrin development. We are dedicated to providing our clients with the highest quality professional services.
Cyclodextrins are enzyme-modified starch derivatives, cyclic oligosaccharides containing six (α-cyclodextrin), seven (β-cyclodextrin), eight (γ-cyclodextrin), or more (α-1,4-)-linked D-glucopyranose units. The cyclodextrins have toroidal shapes, with the smaller and the larger pockets of the toroid exposed to the solvent secondary and primary hydroxyl groups respectively. As a consequence of this arrangement, cyclodextrins can host plenty of hydrophobic molecules, or part of them inside their cavity through non-covalent interactions to form host-guest type clathrate. Cyclodextrin clathrate containing hydrophobic molecules can penetrate body tissues, these could be used to release biologically active compounds under specific conditions. Cyclodextrins are chemically versatile and can be modified to get mono- or poly-substituted derivatives, which can improve their properties (i.e., solubility and stability), and tune their complexation abilities. The complexation process leads to significant changes in guest spectral properties, reactivity, volatility, solubility, and stability. In addition, they are widely used in food, pharmaceutical, agriculture, and chemical industries, as well as the cosmetics industry, oilfield applications, and biotechnology fields.
Fig.1 Structure of Cyclodextrins. (Li, 2007)
Cyclodextrins have been utilized in a diversity of technological fields. For instance, the development of new and improved analytical technologies using cyclodextrins is highly valuable for the pharmaceutical field. With a professional synthesis platform, CD BioGlyco provides our clients with scientific assistance in the research of cyclodextrins. Particularly, we provide several strategies to prepare cyclodextrins-guest complexes including kneading, grinding, microwave irradiation, supercritical carbon dioxide, co-precipitation, and spray-dried. The cyclodextrins-guest complexes can be applied to the development of pharmaceutical and non-pharmaceutical cyclodextrins.
CD BioGlyco is committed to the development of pharmaceutical cyclodextrin to provide customers with reliable products. For example, we provide you with cyclodextrins that can be used in the development of mucoadhesive gels, creams, and films for antifungal and antiviral activities.
CD BioGlyco provides our customers with professional and rapid solutions in the field of non-pharmaceutical cyclodextrin development. For instance, cyclodextrins can be prepared as a stabilizing or thickening agent in the food industry and they can also be used as enzyme mimics in the catalysis.
Comprehensive analytical characterization of cyclodextrin complexes is essential to provide adequate support for the selection of the most suitable cyclodextrin for each guest molecule. Over the years, CD BioGlyco has developed a variety of cyclodextrin analysis methods, such as NMR, HPLC, MS, IR, GC, etc.
CD BioGlyco is the most reliable partner with lots of experienced scientists. We are committed to providing you with high-quality analysis services and reliable products of cyclodextrins. If you are interested in our services, please contact us for more details.