October 9, 2025
Glycosylation Switches & PROTACs – More Precise Targeted Protein Degradation Therapies
On September 12, 2025, a team led by Christina M. Woo of Harvard University published an article titled "Enzyme-Activated Sugar-Coated Bifunctional Degraders" in the journal JACS. This study utilized O-GlcNAc glycosylation as a metabolic switch to design a sugar-coated PROTAC. This molecule activates its degradation function only after deglycosylation of the overactive O-GlcNAcase (OGA) in […]
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