Glycoproteomics

Glycosylation is one of the most complex post-translational modifications of proteins. Minute structural differences in a single N-glycan chain can directly determine a protein's fate within the body, its half-life, and even its functional output. However, due to the high degree of structural microheterogeneity and non-linear complexity inherent to glycan chains, the scientific community has […]

Hepatocellular carcinoma (HCC) ranks among the malignancies with the highest mortality rates globally. Current clinical surveillance strategies primarily rely on abdominal ultrasound combined with alpha-fetoprotein (AFP) testing; however, the insufficient sensitivity of AFP often leads to the missed diagnosis of a significant number of patients in the early stages of the disease. In recent years, […]

Scientists have discovered a class of RNA modified with sugar molecules (GlycoRNA) on the cell surface. These RNAs act like "molecular sponges," adsorbing the pro-angiogenic factor VEGF-A and thus precisely controlling blood vessel development. This discovery rewrites our understanding of extracellular RNA function, opening up new avenues for treating cancer and cardiovascular diseases. Background: When […]

Early detection of cancer and prediction of treatment response continue to face significant challenges. Recently, liquid biopsies have been further extended to analyze Glycoproteins. Glycoproteins are products of post-translational modifications of proteins and play a key role in normal and pathological processes, including cancer. Glycoproteomic analysis has emerged as a promising tool for the discovery […]