Glycoproteomics

Site-Specific <em>N</em>-Glycosylation of A2M Tracks Schistosome-Induced Liver Fibrosis
September 11, 2026

Site-Specific N-Glycosylation of A2M Tracks Schistosome-Induced Liver Fibrosis

Schistosomiasis is a neglected tropical disease that quietly destroys livers. When the worms take up residence in blood vessels and shed eggs into the liver, the host's immune response builds granulomas that, over years, harden into portal fibrosis. The damage is often irreversible by the time symptoms appear, which is why a non-invasive way to […]

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The Mouse <em>N</em>-Glycoproteome Atlas: Tissue-Specific Glycan Signatures Decoded
May 18, 2026

The Mouse N-Glycoproteome Atlas: Tissue-Specific Glycan Signatures Decoded

Glycosylation is one of the most complex post-translational modifications of proteins. Minute structural differences in a single N-glycan chain can directly determine a protein's fate within the body, its half-life, and even its functional output. However, due to the high degree of structural microheterogeneity and non-linear complexity inherent to glycan chains, the scientific community has […]

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Serum <em>N</em>-Glycomics: A New Paradigm for Early Diagnosis of Hepatocellular Carcinoma
April 10, 2026

Serum N-Glycomics: A New Paradigm for Early Diagnosis of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) ranks among the malignancies with the highest mortality rates globally. Current clinical surveillance strategies primarily rely on abdominal ultrasound combined with alpha-fetoprotein (AFP) testing; however, the insufficient sensitivity of AFP often leads to the missed diagnosis of a significant number of patients in the early stages of the disease. In recent years, […]

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A Novel Mechanism for GlycoRNA Regulating VEGF Signaling
March 16, 2026

A Novel Mechanism for GlycoRNA Regulating VEGF Signaling

Scientists have discovered a class of RNA modified with sugar molecules (GlycoRNA) on the cell surface. These RNAs act like "molecular sponges," adsorbing the pro-angiogenic factor VEGF-A and thus precisely controlling blood vessel development. This discovery rewrites our understanding of extracellular RNA function, opening up new avenues for treating cancer and cardiovascular diseases. Background: When […]

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Glycoproteome - A New Frontier in Cancer Biomarker Discovery
July 26, 2024

Glycoproteome - A New Frontier in Cancer Biomarker Discovery

Early detection of cancer and prediction of treatment response continue to face significant challenges. Recently, liquid biopsies have been further extended to analyze Glycoproteins. Glycoproteins are products of post-translational modifications of proteins and play a key role in normal and pathological processes, including cancer. Glycoproteomic analysis has emerged as a promising tool for the discovery […]

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Site-Specific <em>N</em>-Glycosylation of A2M Tracks Schistosome-Induced Liver FibrosisSite-Specific N-Glycosylation of A2M Tracks Schistosome-Induced Liver Fibrosis