Non-Pharmaceutical Cyclodextrin Development

Non-Pharmaceutical Cyclodextrin Development

Due to their property of forming host-guest type inclusion complex, cyclodextrins and their derivatives have a large number of practical applications including foods, cosmetics, textiles, catalysis, agrochemistry, biotechnology, separation, and environmental protection. CD BioGlyco has the confidence to be your essential research assistant in the field of non-pharmaceutical cyclodextrin development.

Applications of Cyclodextrins

Non-Pharmaceutical Cyclodextrin Development

Non-Pharmaceutical Cyclodextrin Development

Non-Pharmaceutical Cyclodextrin Development

Foods

The addition of β-cyclodextrin as a stabilizing or thickening agent can help to retain some aroma compounds in food matrices during cooking, pasteurization, and other thermal processes. To suppress unpleasant odors or tastes, cyclodextrins also can be used to remove or mask undesirable components. Moreover, the formation of inclusion complexes with cyclodextrins can protect some food components that are sensitive to degradation by oxygen, heat, or light.

Biological fields

Scientists have combined the host-guest recognition of cyclodextrin and adamantane with hyperbranched polyethyleneimine (PEI) and have synthesized hyperbranched PEI tubular micelles, which is a promising candidate gene carrier. In addition, porphyrinoids can mimic the functions of natural structures in light-harvesting systems. Cyclodextrins improve the photosensitizing properties of porphyrinoids by increasing their singlet oxygen quantum yield.

Cosmetics

Encapsulation techniques using cyclodextrins as (nano)encapsulating agents are increasingly used by cosmetic, fragrance, and flavor industries, toiletry and personal care sectors for improving the efficiency of odorant and aroma substances, odor control in perfumes, masking unpleasant smells and tastes of some compounds, improving the physical and/or stability of essential oils and volatile compounds, stabilizing volatiles by reducing or eliminating any losses through evaporation.

Environmental protection

Cyclodextrins play a crucial role in the field of environmental science concerning the enhancement and elimination of organic pollutants and heavy metals from the soil, water, and atmosphere and the solubility of organic contaminants. Cyclodextrins are also put into application in water treatment for enhancing the stabilization aspect, encapsulation, and adsorption of contaminants. One can get rid of extremely poisonous and lethal substances from industrial effluent by forming the inclusion complexes.

Catalysis

One of the most promising roles of cyclodextrins is in catalytic reactions. They have the capability to function as enzyme mimics. These are fabricated by changing the naturally occurring cyclodextrins with the substitution on its primary or secondary face with different functional groups or attaching various reactive groups. The substituted groups attached to the cyclodextrin molecule are responsible for the molecular recognition which makes the modified cyclodextrins beneficial as enzyme mimics.

Separation process

One of the main uses of cyclodextrins is as chemically bonded or sorbed ligands in the stationary phase or immobile phase during the separation process. Presently, cyclodextrins along with their derivatives are widely used in the case of chiral separations. In addition, hydrophilic cyclodextrins have been more commonly used as buffer modifiers in capillary electrophoresis to accomplish the chiral separation of drugs and specialty chemicals.

Textiles

Cyclodextrins have the capability to form inclusion complexes with a large number of organic molecules, and this property is responsible for its use in a variety of different textile applications. Since cyclodextrins can incorporate different dyes into their cavity, they should be able to act as retarders in a dyeing process.

Agrochemistry

Cyclodextrins can effectively encapsulate or bind the pesticide’s active ingredients in the material’s matrix with a sustained release profile and slow mobility in soil. Cyclodextrin molecules form complexes with a wide variety of agricultural substances such as insecticides, fungicides, herbicides, repellents, pheromones, and growth regulators.

Our Services

We provide customers with a wide range of cyclodextrins for commercial products and product development, and screen cyclodextrin derivatives to find suitable candidates that meet our clients' requirements.

  • We have developed a range of cyclodextrins, which are used as food additives to stabilize flavors, remove unpleasant tastes and other undesirable compounds such as cholesterol, and eliminate microbial contamination and browning reactions.
  • We provide the dry form of cyclodextrin powders, which are used for odor control in products like diapers, menstrual products, paper towels, etc.
  • The synthesis of superparamagnetic iron-oxide nanoparticles and their nanocomposites with β-cyclodextrins is used for water purification.
  • β-cyclodextrin and γ-cyclodextrin binding carboxymethyl chitosan (CM-chitosan) and carboxymethyl cellulose (CM-cellulose) as deodorants, which worked successfully on limonin, naringin, and caffeine.
  • The complex of cyclodextrins and several substrates or cofactors (e.g., chlorogenic acid, polyphenols, cinnamic acid, Cu2+) can provoke the inhibition of pro-browning polyphenol-oxidase reactions.
  • Providing the modified cyclodextrins beneficial as enzyme mimics in the catalysis.

Advantages of Us

  • Experienced and well-trained researchers
  • Wide range of cyclodextrins applications
  • Customize protocols for different synthesis needs
  • Design, production, and analysis one-stop service

CD BioGlyco is committed to providing non-pharmaceutical cyclodextrin products to our customers. If you would like more details, please contact us.

Reference:

  1. Sharma, N.; Baldi, A. Exploring versatile applications of cyclodextrins: an overview. Drug delivery. 2016, 23(3): 729-747.
This service is for Research Use Only, not intended for any clinical use.

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