Lotus tetragonolobus Lectin (LTL) Production Service at CD BioGlyco

CD BioGlyco has a number of experts in lectins to support tailored Lectin Production services. LTL was discovered in 1948 and consists of 240 amino acid residues. It is a glycoprotein consisting of four subunits and requires metal ions for carbohydrate-binding activity. Currently, LTL has been isolated from L. tetragonolobus seeds. It is found to agglutinate human O(H) erythrocytes. It also recognizes N-acetylglucosamine antigen on carbohydrate chains. At present it is used in the detection of certain diseased tissues in the kidney and so on, which has a good application prospect. Based on this, we develop a one-stop LTL production service. A wide range of products are available.

Fig.1 Process of LTL production. (CD BioGlyco)

L-fucose is found to have the strongest inhibitory effect on LTL. It also has carbohydrate specificity for β-fucose. Our production service is based on the sugar-binding specificity of LTL and reported methods obtained by chromatography and affinity precipitation purification. With our extensive experience in Plant Lectin Production, we successfully extract high-purity LTL from L. tetragonolobus seeds. We also use purified LTL producing a variety of lectin conjugates including colloidal gold conjugate, biotin conjugate, etc. All products are validated by various methods.

Applications of LTL Production

• We produce LTL for the detection of glycan antigens on their recognized carbohydrate chains.
• We produce LTL that is used for glycan localization and change detection, which helps to screen for new disease markers.
• We have fluorescently labeled LTL, including FITC conjugate and rhodamine conjugate, which is used for lectin staining.

Advantages of Us

• Our products contain a variety of markers. We meet the research needs of our clients in areas not used.
• Relying on advanced technology and rich experience in lectin production, we continue to provide clients with high-quality products and good production service.

At CD BioGlyco, products are supplied on time with prompt service response. Besides LTL, we also provide Laburnum alpinum Lectin Service, Lens culinaris Lectin Service, and other production services. Please feel free to contact us for detailed information on LTL and other products.