November 20, 2025
Glycometabolic Modification Drives a Novel Mechanism of Macrophage-Mediated Tumor Promotion
On June 19, 2025, a team led by Hang Yin from Tsinghua University published a research paper in Cell Chemical Biology titled "EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses," revealing a novel mechanism by which glucose metabolic reprogramming in the tumor microenvironment regulates macrophage fate through O-GlcNAcylation. In […]
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