Enzymatic Glycosylation

Enzymatic Glycosylation and Amidation Deliver Safer and More Potent Polyene Antifungals
August 28, 2026

Enzymatic Glycosylation and Amidation Deliver Safer and More Potent Polyene Antifungals

Fungal infections cause severe global mortality, yet the antifungal pipeline has changed little in decades. Amphotericin B and nystatin, polyene macrolides discovered in the mid-twentieth century, remain frontline drugs precisely because fungi rarely evolve resistance to them, but also because almost nothing better has reached the clinic. A Nature study breaks this long stalemate by […]

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