June 12, 2026
One-Pot α-Sialylation Streamlines Sialoglycan Synthesis
Sialic acids cap the termini of many mammalian glycoproteins and glycolipids, where they govern immune recognition, host–pathogen interaction, brain development, and tumor progression. Yet accessing homogeneous sialoglycans—the glycans that carry these residues—remains a long-standing bottleneck in carbohydrate chemistry. A recent study by Zhang et al. (2026) introduces a practical solution: a one-pot α-sialylation protocol built […]
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