Leprosy

Highly Fucosylated, Poorly Sialylated: The Fc Glycan Signature of Anti-PGL-I IgG1 in Leprosy
August 21, 2026

Highly Fucosylated, Poorly Sialylated: The Fc Glycan Signature of Anti-PGL-I IgG1 in Leprosy

Leprosy remains a major neglected tropical disease, and its most severe presentations are marked by a paradox: patients with disseminated infection carry high titers of antibodies against Mycobacterium leprae, yet those antibodies do not appear to control the bacterium. A study in iScience asks why, and points the answer at the sugar decorations on the […]

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