Properties
Description
Doxorubicin-chondroitin sulfate nanoconjugate utilizes hydrazone linkages for pH-sensitive drug attachment, combining anthracycline cytotoxicity with chondroitin's tumor-homing capability.
Glycan Name
Chondroitin sulfate
Glycan Structure
The glycan structure of chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) composed of repeating disaccharide units. Each unit consists of:
N-acetyl-D-galactosamine (GalNAc) (β1→4 linked)
D-glucuronic acid (GlcA) (β1→24 linked)
Source
Chemical synthesis
Functional Group
Doxorubicin
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Chondroitin sulfate-doxorubicin can be used for its potential to optimize anthracycline delivery to minimize cardiotoxic side effects.
