Properties
Description
GE11 peptide-chondroitin sulfate EGFR-targeting conjugate optimizes receptor affinity through C-terminal amidation during solid-phase conjugation to chondroitin's carboxylic groups.
Glycan Name
Chondroitin sulfate
Glycan Structure
The glycan structure of chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) composed of repeating disaccharide units. Each unit consists of:
N-acetyl-D-galactosamine (GalNAc) (β1→4 linked)
D-glucuronic acid (GlcA) (β1→42 linked)
Source
Chemical synthesis
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Chondroitin sulfate-GE11 peptide can be used for its potential to study methotrexate conjugation efficiency in rheumatoid arthritis models.
