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Ko-143, Purity ≥98%
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Cat. No.: X24-09-YM789

Ko-143, Purity ≥98%

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Synonym: 461054-93-3; Ko 143; Ko143; Tert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate

  • MDL: MFCD11042273
  • CAS Number: 461054-93-3
  • Compound CID: 10322450
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Product Size
5 mg; 10 mg; 25 mg; 50 mg
Price
Datasheet
Datasheet
MSDS
MSDS
Properties
Description
Ko-143, soluble in DMSO and ethanol and insoluble in water, is a potent and selective inhibitor of breast cancer resistance protein multidrug transporter (BCRP). The molecular weight of the compound is 469.59, and its molecular formula is C26H35N3O5.
Molecular Weight
469.59
Molecular Formula
C26H35N3O5
Form
Lyophilized powder
Purity
≥98%
Impurities
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.
Solubility
In vitro: DMSO: 89 mg/mL (189.53 mM); Water: insoluble; Ethanol: 89 mg/mL (189.53 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
Ko-143 can be used for its potential to overcome drug resistance in cancer therapy by enhancing the efficacy of chemotherapeutic agents that are substrates for this transporter.
Publications
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