Properties
Description
Paclitaxel-conjugated chondroitin sulfate exemplifies a drug-polymer hybrid where the chemotherapeutic agent is directly bonded to chondroitin sulfate, leveraging glycosaminoglycan transport mechanisms while maintaining paclitaxel's pharmacological potency.
Glycan Name
Chondroitin sulfate
Glycan Structure
The glycan structure of chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) composed of repeating disaccharide units. Each unit consists of:
N-acetyl-D-galactosamine (GalNAc) (β1→4 linked)
D-glucuronic acid (GlcA) (β1→8 linked)
Source
Chemical synthesis
Functional Group
Paclitaxel
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Chondroitin sulfate-paclitaxel can be used for its potential to allow precise examination of hydrophobic drug solubilization in aqueous environments.
