Properties
Description
Pemetrexed-chondroitin sulfate conjugate employs glutaraldehyde crosslinking to attach the chemotherapeutic agent while maintaining both components' pharmacological profiles through spacer arm integration.
Glycan Name
Chondroitin sulfate
Glycan Structure
The glycan structure of chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) composed of repeating disaccharide units. Each unit consists of:
N-acetyl-D-galactosamine (GalNAc) (β1→4 linked)
D-glucuronic acid (GlcA) (β1→18 linked)
Source
Chemical synthesis
Functional Group
Pemetrexed
Impurities
No visible impurities to the naked eye.
Solubility
This product is soluble in most organic solvents, such as DCM, DMF, DMSO, and THF, and exhibits excellent solubility in water.
Identity
Confirmed by NMR.
Applications
Chondroitin sulfate-pemetrexed can be used for its potential to test antifolate polymer conjugates in multidrug-resistant cancer models.
