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<i>De Novo</i> and Salvage Synthesis Pathways of Purine Nucleotides
October 11, 2024
De Novo and Salvage Synthesis Pathways of Purine Nucleotides

As the basic components of RNA and DNA, purine nucleotides play an important role in cellular material metabolism and energy metabolism. For this reason, cells need an adequate supply of purine nucleotides to meet the needs of growth and proliferation. However, we still do not know how normal or malignant tumor tissues maintain nucleotide metabolic […]

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New Strategy for Nucleotide Sugar Synthesis - Engineering Yeast to Synthesize 7 UDP-Sugars
September 20, 2024
New Strategy for Nucleotide Sugar Synthesis - Engineering Yeast to Synthesize 7 UDP-Sugars

Nucleotide Sugar is an activated form in the process of sugar conversion and synthesis, widely present in eukaryotes and prokaryotes. It is essential for the operation of physiological functions and even survival of organisms as a glycosyl donor in polysaccharide synthesis. Structurally, nucleotide sugars can be divided into nucleoside monophosphate (NMP)-sugar and nucleotide diphosphate (NDP)-sugar, […]

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